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Butamirate

Chemical name

2-[2-(Диэтиламино)этокс��]этиловый broadcast �льфа-этилбензолуксус ной acid (in the form of citrate)

Gross

C18-H29-N-O3

Of drugs

The drugs-protivokashlevoe, bronhodilatirtee. Reduces anxiety kashlevogo point nose irritation, expands Bronhi.bystro and completely absorbed in the digestive tract. The blood butamirat hydrolyses to 2-fenilmaslana acid and dietilaminoetoksietanola, have a strong pharmacological activity, to a large extent associated with plasma proteins. After receiving 150 mg of syrup C_max the metabolita - 2-fenilmaslana acid, is about 1.5 hours and 6.4 µ g / J When taken one table. depot (50 mg) of the indicators of 2 minutes and 1.4 µ g / ml, respectively. 2-fenilmaslanaya acid in the liver of exposed gidrauxilirovaniu followed with kongugaciei glukuronova acid. All three metabolita (fenilmaslanaya acid dietilaminoetoksietanol, glukuronid) derived mainly from urine. T_1/2 - 6900 (syrup) and 13 h (tabletki-depo). Not koumouliruet.

Indications

Cough (Pertussis, pre - and posleoperazionny period, etc.)

Contraindications

Hypersensitivity, the children's chest age : drop-up to two months syrup until three years tabletki-depo to 12 years.

Side-Effects

Nausea, diarrhea, dizziness, exantema.

Overdosing

Symptoms : drowsiness, nausea, vomiting, diarrhea, dizziness, blood Gipotenzia.lechenie : activated carbon, salt laxatives, symptomatic therapy.

Dosing and Administration

Inside. Children aged between 2 and 12 months (8 kg) to 10 drops, the children of 1-3 years of age (10 to 15 kg) to 15 drops, for children aged 3 years to 25 drops four times a day; Syrup : children 3-6 years (15-22 kg) to 1 c.lojke, 6-9 years (22-30 kg) to 1 st.lojke three times a day over nine years (40 kg) on January st.lojke four times Sutki.vesroslam-2 st.logki three times a day; Bean : children 6-12 years, and 1 tablet twice a day, over 12 years - one tablet three times a day, adults-2 tablets 2-3 times a day (every 12 hours); tabletki-depo (not liquid, it is desirable to go) : children over 12 years in the table 1. 1-2 times a day, adults on one table. 2-3 times (through 12 p) a day.

See also