Directory → Organotropona funds → Respiratory funds → Secretolitiki stimulants and motor function airways
This page is translated automatically with a help of Google Translate
Secretolitiki stimulants and motor function airways
The groupIn therapy bronholegochnykh diseases with a cough hard to peel mocrotoi commonly used drugs to stimulate extract and collectively referred to as secretomotornah. There are two groups of agents differ on the mechanism secretomotonego action. Thus, drugs 1.31, istoda, stockings and other medicinal plants, terpingidrat, likorin, essential oils have little irritating effect on the skin mucous membrane stomach and then (after a one-emetic centre oblong brain) laser stimulation bronchial glands and salivary glands. In contrast, sodium and potassium iodide, Ammonium chloride and some other after taking inwards and absorption in the bloodstream system are mucosa bronchi, stimulating the secretion of bronchial and partly razjijaya sputum. Overall, Representatives of both groups increased physiological activity mertzatelnogo cancer and respiratory irritative bronhiol, coupled with a slight increase in bronchial secretions glands and low viscosity lower rates.
Widely used in clinical practice бронхосекретолитичес кие drugs (or mukolitiki). It has been shown that the flow properties of specimens (viscosity, elasticity, adgezivnosti) determine freely its offices (expectoration). The mukolitiki particularly useful in diseases of the respiratory system, states, accompanied by the formation of viscous difficult separated patients slizistogo or slizisto-gnoinogo nature, acute and chronic obstruguy bronchitis, pneumonia, bronhoektatical disease bronhiolit, cystic fibrosis, bronchial asthma, atelektaza from mukoidna cap bronchi, in patients with traheostoma, etc. They are often appointed to prevent complications from the operations in the respiratory organs, after intratrahealnogo narcosis.
Among the drugs that have an impact on the flow properties Bronchus secret include enzymes, trypsin, himotripsin, ribonukleaza, desoksiribonukleaza (application is limited by the large number of adverse events), because sulfgidrilnykh groups (acetylcysteine, mesna), derived alkaloid wisitina (bromgexin, ambroxol).
Free sulfgidrile group okislacy, bringing (break) disulfidnye connection acid mucopolysaccharides patients. The macromolecule depolimerizuyutza and culture becomes less viscous and adgezivna. Such products also razzyzaut and gna. Acetylcysteine and 2-меркаптоэтансульфон ат (mesna) are, in addition, the catalytic effect on the mucosal cells, the secret of which is to analyse fibrin and blood clots. Carbozistein, which had sulfgidrillnaya group linked carboximetilna has simultaneously mukoregulirutm and mucolithic effects. The mechanism of action is related to activation sialova transferaza-enzyme bokalovidnykh cells mucous membrane bronchi. Carbozistein standardized quantitative ratio acidic and neutral sialomuzinov Bronchus secret (reduces glikopeptidov neutral, and increases the number of gidroksisialoglikopeptidov) that the suspension of the viscosity and elasticity of mucus. Under preparation regeneration occurs mucous membrane, and restoring the structure, reducing (normalization) bokalovidnykh number of cells, especially in the terminal bronchitis, and hence reduce the number of mucus produced.
In addition restored secretia immunologicaki active IgA (species protection) and the number of sulfgidridnykh groups (nespecifica protection); improving mukotiliarnyi klirens (potenziruetsa activities resnitchatah cells).
Wisitsin (Adhatoda vasica) has been used in the East as a means of soothing. Synthetic homologs - bromgexin (in the body become active metabolite - ambroksol) reduces viscosity secret bronchial glands, provides mukoliticescoe (secretoliticescoe) and the soothing effects. This is due to depolimerizaciei and destruction acid mucoproteins and mucopolysaccharides patients. In addition, bromgexin promotes a neutral polysaccharides and dismisses lizosomaiona enzymes. It is also its ability to restore mukotiliarnyi klirens through activation synthesis surfaktanta alveolarnami pnevmotsytami II order. Thus, bromgexin sit viscous, sticky bronhialny secret and ensures their progress breathing routes. In inflammatory respiratory diseases often use a combination of drugs, including in combination with antibiotics. If you are a mukolitikov and antibiotics should consider compatibility : acetylcysteine in ingalciah instillaceh or not to be confused with antibiotics (mutual inachtiwation); oral azetiltsisteina antibiotics (penicillin, zefalosporin, tetratziklin) should be taken no earlier than two hours; mesna incompatible with aminoglikozidami; carbozistein, bromgexin, ambroxol, on the contrary, increase penetration of Russia in bronhialny secret or the mucous membranes bronchus (primarily concerned Amoxicillin, siruroksima, erythromycin, doxycycline, sulfanilamidov); carbozistein also prevents sgutment patients, provotsyruemomu receiving antibiotics.
In patients with chronic obstructive bronchitis good effect with a combined Bronchiodialator preparations from mukolitikami or each other. Бета_2-симпатомиметик�� (fenoterol, salbutamol, etc.) and theofillin potenziruet mukotiliarnyi klirens; theofillin and m-holinolitiki (ipratropia bromide) reducing inflammation and swelling mucous membranes releases facilitate conversion.