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AmbrobeneSee also Ambroxol
PharmacokineticsIn Injecting a rapidly penetrates the tissues. The highest concentration found in the lungs. Plasma protein binds about 80%. Penetrates the GEB and out with breast milk. T_max achieved after 1-3 hours, T_1/2 plasma in the range of 7-12 hours, and the total T_1/2 plasma (ambroxol and its metabolites) is 22 hours Metabolised in the liver by conjugation with the formation of pharmacologically active metabolites. About 90% of kidney return : 90% in the form of metabolites and 10% unchanged. In heavy Hepatic Cl ambroksola decreases by 20-40%, with heavy human kidney function increases T_1/2 ambroksola and its metabolites.
FarmakodinamikaAfter intake of therapeutic effect occurs within 30 minutes and lasts for 6-12 hours (depending on the dose). In Injecting a force is quickly and continued for 10 hours.
IndicationsBronchitis (acute, chronic), pneumonia, bronchial asthma with othozdenia complication rates, bronhoektatical disease, respiratory distress in premature babies and newborns (injection). For the same reasons for a rapid therapeutic effect or be administered inside-injection.
Pregnancy and lactationApplication during pregnancy, especially during the first trimester, and perid breastfeeding will be valid only if the expected benefits of therapy outweighs the potential risk to the fetus (despite the fact that, until now, there is no reliable data on the negative impact of drugs on the fetus and infants).
ContraindicationsГиперчувствительност ь to components of the drug, saying the disease of stomach and duodenal ulcers, nervous syndrome, limiting the ability of functional kidney severe liver disease, the eye hospital, a large amount allocated secret (risk of stagnation secret bronchitis).
Side-EffectsThe weakness, headache, dry mouth and respiratory passages, excessive salivation, rinorea, gastralgia, nausea, vomiting, diarrhea, constipation, dizuria, exantema; Very rarely, allergic reactions (skin rashes, swelling angioneuroticeski person breathing problems, the reaction temperature to outwardly, allergic contact dermatitis; an isolated incident - anaphylactic Shok.pri rapid on / in a drug-intensive headaches, weakness, a feeling of heaviness in the legs, killing, dizziness, hyperthermia, vomiting.
Specific guidanceWhen administered to flush Pitie.bole, diabetics must take into account that the syrup for the reception inside of sorbit (5 ml syrup contains 2.1 grams of electricity, which is equivalent to 0.175 HE).
Patient interactionThe combined application with protivokashlevami LAN (eg containing codeine) is not recommended because of difficulty breeding rate of bronchus and a reduced flow Kashl.ulucchaet antibiotics (amoxicillin, cefuroxime, erythromycin, doxycycline) in the lung. The mixed solution Ambrobene Solutions with a pH above 6.3.
PrecautionsIf any of the kidneys and / or liver reduce the dose used drugs and increase the interval between meals.
Storage conditionsUnder normal circumstances,
Shelf life5 years
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