Directory → Organotropona funds → Respiratory funds → Secretolitiki stimulants and motor function airways → Bromhexine
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Chemical name2-Амино-3,5-дибром-N-цикл огексил-N-метилбензол��етанамин (and in the form of kamsilata or hydrochloride)
CharacteristicsThe white crystalline powder. It is soluble in water and alcohol.
Of drugsThe drugs-mukoliticescoe, skin, protivokashlevoe. It depolimerizatia mukoproteinovykh and mukopolisaharidnykh polymer molecules (mukoliticeski effect). Does an endogenous surfaktanta ensuring stability alveoli cells in the respiratory tract and their protection from hazards, the improvement of the properties of rock bronholegerngo secret, his slippery epiteliu and the rate of respiratory Putei.pri ingestion (oral solution) for 30 minutes almost entirely (99%) fans. Bioavailability of 80% due to the effects of the "first walk" through the liver. The plasma is associated with proteins. Penetrates the GEB and placental barriers. The liver is demetilirovaniu and stability. Part metabolites formed remains active. T_1/2 to one hour, but the terminal T_1/2 15 hours owing to the slow diffusion back from the tissues. Excreted kidneys. In severe liver failure Cl bromgexina slows and the chronic renal failure that violated its metabolites. When multiple application can koumoulirovati.
IndicationsAcute and chronic diseases bronchus and lung violation othozdenia patients.
ContraindicationsHypersensitivity, pregnancy (especially in the first trimester), breast-feeding (for the period of treatment needs to be reversed).
Side-EffectsGastrointestinal disorders (nausea, vomiting, dispepsia, worsening ulcers), the increase in the aminotransferaz, allergic skin reactions, angioneuroticeski swelling.
Patient interactionKodeinsoderjaschie drugs inhibit releases razzyzenna patients. Is penetration antibiotics (erythromycin, zefaleksin, auxitetratziklin) in the lung tissue.
PrecautionsBe wary appointed to ulcers stomach and duodenal ulcer.
Dosing and AdministrationInside; Adults and children over 14 years in the 8-16 mg; Children under 14 years of age and patients weighing less than 50 kg-8 mg three times daily; Children under 6 years, 4 mg three times a day.
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