Dornase alfa

Characteristics

Rekombinantnaya desoksiribonukleaza rights derived from modified cancer cells homachkov Chinese. Glikoprotein consists of 260 amino acids, molecular mass 37 SD.

Of drugs

The drugs-mukoliticescoe. In inhalation introduction destroys DNA blood of the sputum in lung infections. Decreases viscosity and facilitate the secret, improves the function of external respiration. Reduces the risk of acute lung inhalation Infection.pri a 2.5 mg concentration in sputum from 15 minutes to 3 µ g / ml, and then it gradually declined and by the end of two hours of 0.6 µ g / J Even long Application large doses (up to 10 mg) is not the DNA activity in the serum.

Indications

Dilution and facilitating othozdenia patients with chronic nonspecific lung diseases, pulmonary fibrosis tissue.

Contraindications

Hypersensitivity, allergic reactions to drugs from cancer cells Chinese homachkov, pregnancy, breast-feeding (at the end of treatment), children's age (up to five years).

Side-Effects

Allergic reaction (laringit, pharyngitis).

Specific guidance

We should not confuse the drug inhalation in systems with other medicines, as may decrease its activity.

Patient interaction

Compatible with other drugs (antibiotics, bronhodilatatora, corticosteroids, analgesics).

Dosing and Administration

Inhalation; On the ampoule (2.5 mg) per day; May use two vials per day in older patients. Length receive at least 14 days, the best results (reduction in the incidence of acute infection, the improvement of the external device) met with 6-mesyachnom treatments.

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