Agapurin retard

Roman name

Agapurin # retard

The composition and the form of

1 ml solution for injection contains pentoksifillina 20 mg; Injection in 5 ml, in a Box 5 st.1 tablets - 100 mg; Patients in the dark glass of 60 pcs. , in box 1 flakon.1 retard tablet coated bullets, 400 or 600 mg; blistere in 10 pcs. , in box 2 blisters.

Of drugs

Sossoudorasshiratee, angioproteguoe, antiagregatine, improves microcirculation. Does adenozinove receptors ingibiruet fosfodiesterzu and contributes to the accumulation of platelets Zamf. Decreases agregatia and a juvenile count increases elasticity (deformiroemosti) cells, reduces the viscosity of blood.

Pharmacokinetics

Absorbed fast, extended release form slowly C_max determined after 2 h after administration (12 h decreases to 25% C_max). Distributed evenly, display memory (approximately 94%) and gastrointestinal (about 4%) in the form of metabolites (only about 2% in unmodified form); For the first 6700 return to the 90% rate.

Indications

Human peripheral blood circulation (arteriosclerosis, peremejatayasa limp, diabetic angiopatia, obliteriruty endarteriit etc.), nutritional disorders (postinsultny syndrome, varikoznae ulcers, gangrene, stomach, etc.), angioneiropatia (paresthesia, akrozianoz illness Reynaud); Violations of cerebral circulation (arteriosclerosis), the acute and chronic insufficiency of retinal blood vessels and skin eyes; Acute functional human inner ear.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Acute myocardial infarction, massive bleeding, brain gemorragii.

Side-Effects

Diarrhoeal phenomenon, dizziness, a sense of warmth, itching, urticaria.

Patient interaction

Synergism with hypotensive Programme (simpatolitikami, ganglioblokatorami, vazodilatatorami etc.).

Precautions

Treatment should be under the control of AD : with hypotension and circulatory lability can develop strong gipotenzia and stroke. In heart failure requiring a cardiac glycosides. The diabetes mellitus receiving gipoglikemicakie funds, the appointment of high doses Agapurin may cause concern gipoglikemia, so dose gipoglikemicakih funds must be corrected.

Dosing and Administration

Inside, the food with liquid, squeezed small amounts of liquid, 1 tab. retard twice a day or two tablets three times a day for one week; with a sharp drop AD reduce the dose to 1 tablet three times a day, the same dose used in the long course Lechenia.v / a (struino or drip), in / in (struino or drip), in / m. Dose and treatment scheme are set individually.

Storage conditions

tabl.p.o.retard : List B. In dry place so that the temperature does not exceed 25 ° C

Shelf life

tabl.p.o.retard : 4.5 g.

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