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Alprostan

See also Alprostadil

Roman name

Alprostan

The composition and the form of

1 USD from 0.2 ml concentrate for the infusions (at the absolute alcohol) contains alprostadila 0.1 mg; in a box 10 vials.

Pharmacokinetics

Metabolized in the lungs and 90% (with a single) by the enzyme oxidation with the formation of three biologically active metabolites : 15-keto-pge_1, 15-keto-13 ,14-digidro-pge_1 and 13,14-digidro-pge_1 (PGE_0). Keto-metabolita lower than alprostadilom bilogicakim effect 13,14-digidro-pge_1 metabolite (PGE_0) has comparable to PGE_1 act, but the longer. T_1/2 PGE_1 is 10 and PGE_0-1 min (alfa-faza) and 30 min (beta). Major metabolites derived from the urine of 88% and faeces-12%.

Farmakodinamika

It improves microcirculation force on the blood, expands artery arteriola and relaxes sfinktera prekapillarov; Improves the flow properties of the blood, improves elasticity cells; Influences gemokoagulyatia by reducing the adhesion and agregatia platelets. And fibrinoliticakim effect. Provides antiaterogennoe act slowing activation Klebsiella, excessive proliferatiou cells vascular wall. Do kollateralny bloodstream. The systemic and pulmonary circulation is vazodilatatin. Will increase blood flow in kavernozhnykh Telah.snijaet round, AD gift increases variation, which leads to an increase in heart release. It stimulates smooth muscles bowel, bladder and uterus; Suppresses the secretion of gastric juice.

Indications

Chronic diseases obliterirute arteries limbs III stage (on the classification Fontaine), accompanied by me at peace or trophic changes : obliteriruty endarteriit heavy peremejateisa hromotoy (if not shown surgery), arteriosclerosis arteries limbs; Angiopatia diabetic, a disease Burger, Reynaud syndrome with trophic violations; Vasculit with systemic sclerodermia. Violations of peripheral blood circulation as a result of sverhpredelna vibration. Ductoszawisimae Congenital heart defects in newborns (for the temporary maintenance of the blood flow before the reconstructive surgical operations).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, and acute podostry myocardial infarction, severe pain (including unstable), cardiac insufficiency of the decompensation, adults, bronchoobstructive syndrome severe with signs of respiratory failure, swelling or changes infiltrativee light expressed by the human liver condition characterized risk of hemorrhage (stomach ulcer and duodenal ulcer, heavy defeat cerebrovascular, proliferatius retinopathy tend to bleeding, extensive injuries); joint appointment sosudorasshirath and antikoagulyantnykh funds, pregnancy, breast-feeding; age under 18 years of age (except neonatal period), and over 75. In neonatalogii : oppression of breath, respiratory distress, the spontaneous stoiko-otkrytogo blood flow.

Specific guidance

Solution to the ex tempore. Cooked solution can be stored up to 24 hours at a temperature of 2-8 ° C.

Patient interaction

Do the anti, gipotenziveh funds and antiagregantov вазодилататоров.Фарм��цевтически is not compatible with other solutions (with the exception of physiological 5% or 10% glucose solution).

Precautions

The on / in the introduction to the flebita (proksimalnee of introduction). This is generally not a reason for stopping treatment : signs of inflammation disappear in a few hours after the infusions, or the placement of the introduction, special treatment in such cases is not required. Catheterization central junction reduces the frequency of the side effects. The number of unwanted reactions increases depending on the concentration and the speed of the infusions. Increased Infusion should be limited in patients with raised heart failure (risk of lung inflammation and heart failure). Caution must be exercised in patients with arterial hypertension; In older patients with insulinzawisimam diabetes (especially in the big loser receptacles), with a newborn in the case bradeepnoe, arterial hypotension, and tachycardia Gipertermii.pri treatment must be monitored gemodinamicakie parameters KHS, biochemical indicators and parameters of blood coagulation. A sine qua non of the newborn is the possibility of IVL. The drug must be used under medical care Controlem.patienta with heart, renal insufficiency (serum creatinine of more than 1.5 mg / l) shall be supervised in the hospital during treatment and for one day after the end of treatment. To avoid symptom gipergidratace of fluid inclusion should not exceed 100 ml per day. The dynamic monitoring of the patient (Control AD HR), as appropriate, control body weight, the balance of fluid measurement of central venous pressure or Ejocardiografia.u patients gemodialise drug treatment should be postdializnom Periode.u patients with chronic diseases obliterirutmi arteries lower limbs drug use is part of a comprehensive treatment, and the clinical effects may occur after treatment.

Storage conditions

List B. In a dry, the dark place at a temperature of 1-5 ° C (not freezing). Cooked solution is not more than 24 hours

Shelf life

2

The registration

012232/01-2000

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