Pentoksifillin

Roman name

Pentoxifylline

The composition and the form of

1 USD 5 ml solution for injection contains pentoksifillina 20 mg; in a cardboard bundle 10 pcs. , complete with a knife ampulnam.

Dosing and Administration

Assign pentoksifillin inwards intravenously and vnutriarterialno. Inside are from 0.2 g (2 pills), 3 times a day after meals, not liquid. After the therapeutic effect (usually after 1-2 weeks). Reduce the dose to 0.1 g (1 tablet) three times a day. The course of treatment is two to three weeks. and more.

Storage conditions

r-r d / in. : List B. In the dark place at room temperature

Shelf life

r-r d / in. : 2 grams.

Of drugs

Tiklopidin is a strong inhibitor of aggregation of platelets (Figure prevents platelets), adenosindifosfatom caused, and he also ingibiruet agregatia caused by collagen, adrenalinom, arahidonova acid trombinom and trombotsitnam aguirutm factor. The ingestion of tiklopidin depending on the time and dose inhibition of aggregation of platelets, as well as prolongirovanie (extension) of the time of bleeding. Once inside tiklopidin effect on the functions of mitochondrial membranes, ingibiruya by ADF tying nine. Maximum inhibition of aggregation of platelets is a 11 days after the receipt of the tiklopidina bleeding and other functions platelets are the norm in the next two weeks, most of the patients.

Indications for use

Violations of peripheral arterial and venous diseases, including against atherosclerosis, diabetes obliterirauchego endarteriita (inflammation of the inner lining of arteries limbs, with its requirement). Violations of trophic (nutrition tissue), postinsultny syndrome (the patient's post-stroke), varikoznae ulcer (izgyazwlenia locally advanced veins), gangrene (tissue eliminate their drying or gnilostnam disintegration), mad. Angioneuropatii - parestesia (feeling numb limbs), akrozianoz (posinenie from the fingertips, lips, nose), a disease Reynaud (reduced clearance receptacles limbs). Heart of cerebral circulation, including the cerebral farm (disease of the brain which had to reduce their clearance). The ishemicski after stroke (insufficient supply tissue of the brain of oxygen due to the severe violations of cerebral circulation), or haemorrhagic stroke (acute human cerebral circulation as a result of the dissolution of the brain). Violation of eye diseases (acute and chronic insufficiency of retinal blood vessels and membranes eyes). Acute functional human inner ear. (See also p. 205).

Side-Effects

Constipation, pain in the stomach, skin allergic reactions, dizziness, in some cases, jaundice. There phenomenon hemorrhagic (bleeding), trombopenia (reduced platelets in the blood), lakopenia (to reduce blood in the blood), agranulozitos (dramatic decrease in the number of granulospov in the blood). The treatment must be systematically hematologic studies (study of blood) and the monitoring function of the liver.

Contraindications

The drug is contraindicated patients with increased risk of bleeding, and acute ulcers stomach and duodenal ulcers, acute gemorragicescom stroke (acute human cerebral circulation as a result of the collapse of the brain), liver diseases, pregnancy and breastfeeding. Do not assign product at the same time as antikoagulyantami (means halting down blood) and other antiagregantami (azetil-salicilova acid, etc.).

Form of

Pill (CT) to 0.1 grams per package of 60 pieces; Retard tablets 400 mg in a package of 50 pieces; Retard tablets 600 mg per pack to 20 pieces; 2% solution in sealed to 5 ml in a package five vials.

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