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MicardisSee also TelmisartanRoman nameMicardisPlusPharmacokineticsIf ingestion is rapidly absorbed from the digestive tract. Bioavailability of 50%. Together dietary intake reduction AUC ranged from 6% (dose of 40 mg) to 19% (at the dose of 160 mg). After 3 h after administration concentration in plasma aligned regardless of the administered erh or with food. C_max and AUC 3 and 2 times, respectively, higher for women than men without meaningful impact on the concentration. Linking plasma protein - 99.5%, mainly albuminom and alfa_1 glikoproteinom. Mean apparent volume of distribution in the equilibrium phase-500 litres. Metabolised by the kongugirovania glukuronova acid. Metabolites pharmacologically inactive. T_1/2 for more than 20 hours Total plasma high Cl (900 ml / min) compared with pechenocnam bloodstream (about 1500 ml / min). Return via intestine unchanged to the moving tribute, less than 2%.Clinical pharmacologyThe maximum effect is after 3 h after a single reception. Gipotenzivne effect persists for more than 24 hours, including the recent 6700 before receiving the next dose. Stable clinical performance is achieved through the 4-8 weeks of the course and the long-term support. In a dramatic admission AD gradually (in a few days), returning to baseline values with a "ricochetna" hypertension.IndicationsArterial hypertension.Pregnancy and lactationContraindicated in pregnancy. At the time of treatment should stop breastfeeding.ContraindicationsHypersensitivity, violations road psoriasis ways expressed by the human liver and kidneys, genetic intolerance fruktozy, pregnancy, breast-feeding, childhood and adolescence.Patient interactionTiazidnye dioretiki (e.g. hydrochlorothiazide) increase gipotenzivne of telmisartan. Telmisartan increases gipotenzivny effect antigipertenziveh other drugs increases the concentration of digoxin in the blood.PrecautionsFor dehydrated patients with giponatriemii (dioretikami treatment, restriction of salt, diarrhoea, vomiting), it is recommended to decrease Dozy.s caution appoint patients with stenosis bilateral renal artery stenosis or renal artery only functioning kidney (it increases the risk of severe hypotension and renal failure), stenosis arteries and mitral valve obstruction gipertroficescoy cardiomiopatiei, kidney and / or liver, severe heart failure (giperkaliemia possible, and therefore there is a need to monitor the level of potassium and creatinine in the serum), the disease Jkt.nelia use in the primary and aldosteronizme congenital fruktozy intolerances (1 table. 40 mg and 80 mg contain 169 mg and 338 mg electricity respectively). The planned pregnancy recommended in the product antigipertenzive other means. If a pregnancy should immediately stop receiving Micardis. Be wary of during the drivers of vehicles and people skills relate to the high concentration of Vnimania.pri simultaneously with a drug lithium requires monitoring of the content in the serum, perhaps transient increased (and toxicity) of lithium in the plasma.Storage conditionsList B. In safe dry place so that the temperature does not exceed 30 ° CShelf life4The registration015387/01 |
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