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Teveten

See also Eprosartan

Roman name

Teveten

Characteristics

Axura receptors angiotenzina II.

Pharmacokinetics

Absolute bioavailability of the drug intake of a single dose is about 13%, due to the limited intake of the digestive tract. When taken into prandial C_max in plasma is achieved in 1-2 hours Admission at the time of delivery was down eprosartan intake and low (25%) with no clinical significance C_max changes in plasma. The binding protein with high blood (99%) and constant in the range of concentrations achieved after receiving therapeutic doses, is not dependent on gender, age, liver function, mild or moderate violations funtion kidney, but reduced to a small number of patients with severe renal недостаточностью.Пос��е Admission into print with urine and faeces, predominantly (up to 80%) in an unmodified form. With long-term use only 26.3. C_max value in the blood increases in patients aged patients (average approximately 2 times), and in patients with hepatic insufficiency (an average of about 40%) but it does not require a change in regime Dozirovania.srednie concentrations eprosartan in patients with moderate renal insufficiency (Cl creatinine 30-59 ml / min), approximately 30% higher than in patients with normal renal function, and in patients with severe renal insufficiency (Cl creatinine 5-29 ml / min), approximately 50%. It also does not require a change in regime дозирования.Фармакок��нетика Teveten men and women equal.

Farmakodinamika

Antagonisticski ingibiruet the angiotenzina II AD kidney bloodstream and aldosterone secretion from the healthy people. Angiotenzin II, is the most active hormone ренин-ангиотензин-аль достероновой system has been playing a major role in the pathophysiology hypertension, binds to receptors in many tissues (such as the muscular wall receptacles napochechnikah, kidney, heart), and is vazokonstricciu, sodium delay and the release of aldosterone. Later angiotenzin II involved in the genesis of thyroid diseases and receptacles as a result of its action on the growth of cells attack and smooth Musculatura.u patients suffering from arterial hypertension, sufficient control AD achieved if the daily dose of the drug is taken as the one taking over or divide it into two reception. Permanent and soft gipotenzivny effect maintained for a period of 24 hours without development arterial Orthostatic Hypotension in response to the first dose. The treatment is not accompanied by the syndrome. Lower AD in patients with arterial hypertension is changing curves. No impact on the concentration of blood triglycerides, total cholesterol, or cholesterol in the quantum, glucose. Saves kidney function in patients essencialna arterial hypertension, and in patients with renal insufficiency. It reduces the speed clubockova filtering healthy men, in patients with arterial hypertension or renal failure of varying degrees of severity. It natriyureticeski effect on healthy people in giponatrieva diet. Has no meaningful action on the removal of uric acid in the urine and not potenziruet effects (including cough), associated with bradikininom (and oposreduyemye ACE).

Indications

Arterial hypertension.

Pregnancy and lactation

Contraindications. Experience in applying during pregnancy negligible. Products which have a direct effect on the ренин-ангиотензин-аль достероновую system that can cause disease and death of the foetus and the newborn at the time of appointment in Groups II and III trimestrah pregnancy.

Contraindications

Гиперчувствительност ь to components of the drug, pregnancy, lactation, children's age (security and the effectiveness of the unknown).

Side-Effects

Angioneuroticeski swelling (rarely).

Patient interaction

Clinically significant drug interactions were observed. No impact on farmakokinetiku digoxin, farmakodinamiku racumin, glibenklamida. Not seen changes pharmacokinetics at the same time with the application of ranitidine, ketokonazolom, flukonazolom. Teveten can be safely combined with dioreticakimi means a tiazidov (eg gidrohlortiazidom) and BAC (eg nifedipinom prolonged action), if necessary. Secure a combination of the lipid control (lovastatinom, simwastatinom, prawastatinom, fenofibratom, gemfibrosilom, niacin).

Precautions

It is awake and does not affect the ability to drive, as well as to work on the machines and Mehanizmah.v currently has insufficient experience in the treatment of patients with severe heart failure or renal stenosis artery drugs from the group receptor antagonists angiotenzina II. It is therefore possible deterioration of kidney function because of the oppression ренин-ангиотензин-аль достероновой system.

Storage conditions

List B. The temperature is not above 25 ° C

Shelf life

2

The registration

012018/01-2000

The drug forms

White, kapsuloobraznae tablets, coated films coated.

All products of this group

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