Directory → Organotropona funds → Cardiovascular funds → Antiarrhythmic funds
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The groupNormalizing influence on the broken rhythm of heart may have substance belonging to different classes of chemical compounds belonging to the different pharmacological groups. Thus, in aritmiah related to emotional stress, in patients with severe heart disease antiaritmicski effect can be reassuring (sedatives, trankvilizirute) drugs. Antiaritmicescoy activity, in one way or the other in many of neurotropic (holinoblokatora and holinomimetiki, adrenoblokatora adrenomimetiki and local anaesthetics, some with anticonwulsanta �ротивоэпилептическо�� activity), preparations containing potassium salt, antagonists calcium ions, etc. However, there are a number of drugs, the pharmacological property is normalizing effect on the rhythm of the heart with different types of arrhythmias. These substances, along with бета-адреноблокатора��и antagonists and calcium ions (see Beta-adrenoblokatora and Blokatora calcium channels), some local anaesthetics and others, in connection with their concerns antiaritmicescoy activity together in the group of drugs complications.
There are many classifications complications drugs. The upotrebitina Classification Vogen-villamsa separating antiaritmiki four classes : Class I - мембраностабилизирую щие means (hinidinopodobne); Class II-beta-adrenoblokatora; III-class drugs that slowed repoliarizatia (beta-adrenoblokator sotalol, amiodaron); Class IV-blockers "slow" calcium channels (antagonists calcium ions).
In the classroom мембраностабилизирую щих funds allocated three subgroups : IA-quinidine, novokainamid, atmozin, dizopiramid; Group 1B-local anaesthetics (lidocaine, trimekain, piromekain) mexiletin and difenin; Sub-IC aymalin, etazizin, allapinin.
The mechanism of action of drugs complications led them on the cell membrane transport of ions (sodium, potassium, calcium) connected with the change in membrane depolarization building cardiomyocytes and other �лектрофизиологическ��х processes miocarde. Various groups complications and the individual drugs differ on the impact of these processes. Thus, drugs subgroups IA and IC largely suppress transport sodium ions through the "fast" "sodium channels cell membranes. Products Group 1B increase permeability membrane potassium ions. Quinidine concurrently with the oppression transport of sodium ions reduces admission to cardiomiotita calcium ions. Hinidinopodobne substance reduces the maximum speed depolarization, the threshold increases excitability, inhibit conductivity to lift Guisa and Purkinje fibers, slow recovery reactivity membranes cardiomyocytes.
A special mechanism of the main products of Class III-amiodaron (cordaron). Blocking potassium channels membranes cardiomyocytes, it is increasing the length of the building, prolong the momentum in all parts out of the heart, urejaet sinusovy rhythm, it is the extension of the interval channel and do not have a significant influence on the ability Oxytocics attack. Conditional pricislemy to Group III ornid (bretili) has been largely simpatoliticescoe act limiting thus, the impact on the rest miocard; however, it increases like amiodaronu, length of the building.
The action antiaritmicski бета-адреноблокаторо�� is a reversal of aritmogennah sympathetic affects the vascular system of the heart, Electric heterogeneous mechanical and speed of the institution through AV node increases refractornogo period. To some extent antiaritmicescie properties бета-адреноблокаторо�� from the influence of the membrane potassium channels, and the stabilization of potassium ions in miocarde.
Some beta-adrenoblokatora (propranolol, oxprenolol, pindolol, talinolol) have also мембраностабилизирую щей and hinidinopodobna activity.
Antiaritmicski effect of some drugs for metabolic processes (adenosine phosphate), and ion balance (magnesium products, etc.) in miocarde. Products designated magnesium for the prevention of arrhythmias, including in cases of overdose cardiac glycosides, as well as paroxizmah ventricular tachycardia type "pirouette."