Ajmaline

Chemical name

(17R,21альфа)-Аймалан-17,21- диол (and as hydrochloride or phosphate)

Gross

C20-H26-N2-O2

Characteristics

D. contained in certain rauwolfia. White or white with a yellowish sheen crystalline powder, it is difficult soluble in water and alcohol.

Of drugs

The drugs-antiaritmicescoe. Refers to antiaritmikam IA class. Reduces anxiety and airway diseases, automatic sinusnogo hub, AV and vnutrijeludockovu conductivity, lengthens refrakterny period suppresses activity ectopiceskih pockets institute. And simpatoliticakimi properties.

Indications

Paroxizmalnaya najeludochkovaya tachycardia (including the Wpw-sindrome) paroxizmalnaya ventricular tachycardia, Paroxysm times or trepetania predserdy, disruptions in the heart intoxication glycosides, and najeludochkovaya ventricular arrythmia.

Restrictions on the use of

Myocardial infarction (acute stage).

Contraindications

Serious AV and vnutrijeludockova conductivity, skleroticalkie and inflammatory changes infarction, arterial hypotension, cardiac insufficiency III degrees.

Side-Effects

The overall weakness, hypotension, nausea, vomiting; In the on / in the introduction is the feeling of heat.

Dosing and Administration

In / in struino - 0.05 g in 10 ml 5% glucose solution (within 2-4 minutes) or drip 100-200 ml izotoniceski solution of sodium chloride; Re-introduction to a 15-30 min. V / m at 0.05 g every 3-4 hours Supportive therapy : inside-0.05-0.1 g 3-4 times a day. The highest daily intake in Injecting a 0.2 g.

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