Amiodarone

Chemical name

(2-Бутил-3-бензофуранил )-[4-(2-диэтиламино)эток��и]-3,5-дийодфенил]мета heard (and as hydrochloride)

Gross

C25-H29-I2-N-O3

Characteristics

Crystalline powder, white or cream color. Malorastvorim in water, soluble in alcohol, it is readily soluble in chloroform.

Of drugs

The drugs-antiaritmicescoe, antianginalnoe. Lock ion channels (primarily benzene, to a lesser extent, and calzieve sodium) membranes cardiomyocytes and bring down Alpha and бета-адренорецепторо��. Increase the capacity of the cardiac structures at the expense of reducing expressed its amplitude. And hronotroponam negative influence. Simpatolitical activity, and the blockade of potassium and calcium channels reduce the need heart of oxygen, resulting in adverse effects dromotroponomu : down conductivity and refrakterny longer period of sinusnom and AV nodes. With characteristic vazodilatator may reduce coronary resistance сосудов.Биодоступнос��ь after intake of nearly 50%. C_max achieved through plasma 3-7 h after the first dose, the average concentrations in plasma ranges from 1 to 2.5 mg / O Associated with the plasma protein by 96%. And the ability to express accumulation, accumulate in a well perfuziruemah organs (liver, lungs and spleen), and stored in the adipose tissue. Leaving placental barrier (10-50%), and enters the breast milk. The way that, through elixirs (can be a little enteropechenocnaya recycling). There is a low temperature Cl with low renal excretia.

Indications

Heavy infants (generally with poor or no therapy etc.) : predserdnaya and ventricular arrythmia, Wpw-sindrom, fibrillation and began predserdy, ventricular tachycardia, ventricular fibrillace; Witness against coronary, or heart failure, arrhythmia jeludockove in patients with Chagas miocarditom.

Contraindications

Гиперчувствительност ь (incl. to iodine), sinusova aetiology, AV blockade syndrome sinusova insufficient expressed violations conductivity, cardiogenny shock dysfunction thyroid gland.

Side-Effects

Mikrootslaki retina, optic neuritis, hypermarkets (requires removal products), or hypothyroidism, fibrosis lung pnevmonit, pleurisy, bronhiolit, pneumonia, peripheral neuropathy and / or myo, ekstrapiramidnyi tremor, ataxy, brain disorders, nightmares, aetiology, asistolia, AV blockade, nausea, vomiting, the liver, alopecia, epididimit, anaemia, photosensitization, allergic reactions.

Patient interaction

Beta-adrenoblokatora increase the risk of hypotension and bradikardii. Inconsistent with the terms (increased risk of developing AV blockades and hypotension). Holestiramin T_1/2 decreases and the level of evidence in plasma-zimetidin increases. Do proximity effect anticoagulants, drugs naperstanki. Increases in the blood concentration of cyclosporine.

Overdosing

Symptoms : aetiology, gipotenzia, AV blockade, electromechanical dissociation, cardiogenny shock asistolia, cardiac arrest.

Precautions

Ekg-control 6.1.8. Not recommended combined with beta-blokatorami, verapamilom, diltiazem, slabitionami incentives motoriku stomach. Be wary combine with the drugs causing gipokaliemia (dioretiki, corticosteroids, amphotericin B for the under / introductions), and assign patients with severe and prolonged diarrhea. In long-term care needs monitoring tests, regular monitoring functions of the thyroid gland, X control lungs.

Dosing and Administration

In / in, nasashchataya dose, 5 mg / kg for 15 minutes 2-3 times a day supporting therapy, which is 10 to 20 mg / kg / day (250 ml of 5% aqueous solution). Inside, from 100 to 400 mg / day (maximum dose of 600 mg / day) for a period of 8-10 days, possible break-two days a week.

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