Bretilat

Roman name

Bretylate #

The composition and the form of

1 ml solution for injection contains bretilia tosilata 50 mg; in the sealed-2 and 10 ml.

Of drugs

Antiaritmicescoe, simpatomimeticescoe. Blocking potassium channels reduces the norarenalina of vezikul adrenergicakih fibres.

Farmakodinamika

Increases length of the building and effective refrakterny period Purkinje fibers and ventricular cardiomyocytes. Antifibrillaii effect is manifested through the 5-15 min after the introduction, but in some patients, even in a few hours.

Indications

Fibrillace testing (including in the face of resistance to elektroimpoulsnoy therapy), ventricular tachycardia.

Contraindications

Feohromotsytoma, serious violation of cerebral circulation and hypotension, collapse, severe renal failure, stenoses mouth lakes, severe pulmonary hypertension, heart intoxication glycosides, pregnancy.

Side-Effects

Gipotenzia (incl. ortostatical), a modest increase AD and HR (early introduction), nausea, vomiting (with the rapid on / in the introduction), rarely tissue necrosis at the injection (with the / m introduction).

Specific guidance

No data on the use of children doses greater than 5 mg / kg

Precautions

It should be borne in mind that in patients with heart failure gipotenzia can develop even in the rest (if necessary correction of the increased sensitivity to kateholaminam) may increase jeludockovh tachiarrhythmia caused by cardiac glycosides. In the human kidney reduce dosage in accordance with the reduction of Cl creatinine. In overdose effective Hepatology. Nursing mothers at the time of treatment should stop breastfeeding.

Dosing and Administration

In / in, in / m. Adults in / in the fast (in the face of coming events), 5 mg / kg nerazvedennogo drug, in the absence of effects within 5 minutes to re-enter in the same dose, or increasing it to 10 mg / kg in a single introduction. In less serious violations ventricular rhythm is introducing more slowly, in the form of razvedennom (final concentration of 10 mg / ml) : 1 breed of product in the April 5% glucose solution or 0.9% solution of chloride Natria.infuzine introduction : divorced solution imposed for a period of not less than 8 min (better for 15-30 minutes). If the adults dose can be repeated at intervals of 1-2 hours, as a witness supporting the therapy, which is a diluted solution continuously poured at the rate of approximately 1-2 mg / min or give dose of 5-10 mg / kg for 15-30 minutes every six C.v / m introduction : 5-10 mg / kg in the form vanish solution through 6-8 h (with repeated injections changing the place, not more than 5 ml in the same place).

Storage conditions

r-r d / in. : List B. In the dark place at a temperature of no higher than 25 ° C (not freezing)

Shelf life

r-r d / in. : 5 years

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