Bumecaine

Chemical name

1-Бутил-2',4',6'-триметил-2 -пирролидинкарбоксан��лид (as hydrochloride)

Gross

C18-H28-N2-O

Characteristics

White or white with weak Navy crystalline white powder. Rat in the water, easily soluble in alcohol.

Of drugs

The drugs-antiaritmicescoe, местноанестезирующее . And mestnoanestezirutm and antiaritmicski effect. Antiaritmical activity is the stabilizing influence on the cell membrane cardiomyocytes. Does slow current of sodium ions into cells markedly increases the permeability of the membrane potassium ions, accelerating the repolarization, suppresses automaticity ectopiceskih pockets импульсообразования.��естноанестезирующий consequential effect of the stabilization of membranes nervous cells, a decrease in the permeability to sodium ions, which prevent the emergence of potential actions and the nervous Impoulsa.pri local application (ointment), the fast growing in 1-2 minutes and lasts for 30 to 40 minutes.

Indications

Violations heart rhythm : paroxizmalnaya ventricular tachycardia, ventricular arrythmia, incredible in the face of intoxication cardiac glycosides, and myocardial infarct et al. Operations on the heart (for the prevention and treatment), with a temporary and permanent electrostimulation (mild ekstrasistolia). Surface anesthetic in dentistry, ophthalmology and eye, endoscopic studies.

Contraindications

Гиперчувствительност ь. The on / in the introduction : views of the liver and kidney syndrome weakness sinusnogo node (in patients older), Av-blokada II degree, and began predserdy fibrillation; Decompensation diabetes.

Side-Effects

The on / in the introduction : paleness skin and mucous membranes, weakness, nausea, vomiting, headache, dizziness, fear, demotion AD Kollaps.pri local application : when used in high doses can paleness skin and mucous membranes, weakness, nausea, headache.

Specific guidance

In / in the introduction to be carried out only in a hospital environment. In developing hypotension encourages the use of ephedrine or other sossoudossoujiwath funds.

Patient interaction

Quinidine potenziruet risk of side effects.

Dosing and Administration

In jeludockovh aritmiah : in / in struino slowly (1 ml / min) in the dose of 100 mg (10 mL 1% solution boumekaina of 5% glucose solution) for 3-5 minutes; If necessary, be 2-3-kratnoe introduction to the dose of 100 mg every 15 to 20 minutes. The effect protiwaritmicski support in / with the introduction of bacterial Quick 2-3 mg / min (8-12 drops per minute). Acute myocardial infarction : in / in struino slowly, in the dose of 100-150 mg (10-15 ml of 1% solution) within 3-5 minutes (one bolus) either dose of 100 mg (10 mL 1% solution) twice with an interval between wvedeniami 15-20 minutes in the face of a drip (bolus twice in the face Infusion). Infusion duration of 24 hours or more (depending on the nature and the current process and the effectiveness of therapy). The average single dose in the / in a 100-mg, the highest daily intake of 1.5 G.pri operations on the heart : in / in struino slowly (1 ml / min), the dose of 1.5-2 mg / kg for three to five minutes, the effect of support in / infuziei in at the rate of approximately 1-2 mg / min (4-8 drops per minute) within 24 C.poverhnostnaya anaesthesia : in ophthalmology for 1-2 drops 0.5% solution; in the nose-ml 1-5 1-2% solution, if necessary add 0.1% solution adrenalin hydrochloride (1 drop for every 2-3 boumekaina ml); pain in endoscopic studies, 2-5 ml of 2% solution. In dentistry (anaesthesia mucous membranes of the oral cavity), 1-5 ml 1-2% solution, or 5% ointment. Ointment are thin in plot mucous membranes of the oral cavity for 2-5 minutes, or one oven with a maximum dose of 1 g.

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