Disopyramide

Chemical name

альфа-[2-[Бис(1-метилэти л)амино]этил]-альфа-фе��ил-2-пиридинацетамид (and as phosphate)

Gross

C21-H29-N3-O

Of drugs

The drugs-antiaritmicescoe. Decreases speed depolarization (phase 1) and the slope of the spontaneous depolarization (phase 4), because of the blockade "prompt" potassium channels. Refers to antiaritmicski drugs IA class. And inotrope negative effect reduces heart ejection (with increased end diastolic pressure in the left jeludocke) slows conductivity increases round without affecting the HR and AD. Weak holinoblokator. The on / in a narrowing of the coronary vessels and increases the need heart of oxygen. Once inside C_max determined in 2 hours Connection with the plasma protein-50-60%. T_1/2, 6-7 p.m. Report the news (partly in the form of metabolites).

Indications

Jeludockove adults and ekstrasistolia high gradation.

Restrictions on the use of

Pregnancy, breast-feeding (should stop breastfeeding).

Contraindications

Hypersensitivity, cardiogenny shock AV blockade II extent syndrome long QT weakness sinusnogo hub.

Side-Effects

Proaritmogenny effect and hypotension, the progression of heart failure, the expansion of Micro, AV blockade degree I, hypoglycaemia, impaired vision, the vnutriglaznogo pressure xerostomia, atony bowel and bladder, neuralgia, headache, dizziness, allergic reactions.

Dosing and Administration

Daily intake for adults-600 mg, divided into four reception. For children, the average dose of 10-15 mg / kg / sut.

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