Lappaconitine hydrobromide

Chemical name

4-(N-Ацетилантраноилок��и)-8,9-дигидрокси-1альф��,14альфа,16бета-тримето кси-N-этил-18-нораконан�� gidrobromid

Characteristics

D. obtained from wild plants multi akonita belloustogo family toad.

Of drugs

The drugs-antiaritmicescoe. Assists мембраностабилизирую щее act affects sodium channels is a Class IC complications drugs. The slowdown предсердно-желудочко��ой and vnutrijeludockova conductivity, shorter effective and functional refrakternae periods predserdiah jeludockah and does not affect the QT interval, with a conductivity of AV node in anterogranom direction, and choose AD airway segments (in the absence of events heart failure). Provides moderate skin, koronarorasshiratee, holinoliticescoe and sedate действие.Биодоступно��ть 39% is intense presistemna biotransformation. The on / in the introduction and ingestion T_1/2 - 1-1.2 hours, the volume of 42-and 690 litres respectively. Penetrates the GEB. One of the three major metabolites lowers AD. The ingestion effect develops through 40-60 minutes, reaches maximum at 4-5 hours and lasts for eight hours or more. In a / in the antiaritmicescoe to be 15 to 20 minutes and lasts 6-8 hours (with a maximum of two hours). Extension T_1/2 noted in the long-term use, renal failure (2-3 times), cirrhosis of the liver (in 3-10 times).

Indications

Najeludockove and jeludockove adults (ekstrasistolia, paroxizmale tachycardia), incl. in the face of myocardial infarctions and frequent najeludockova tachycardia in Wpw-sindrome, frequent gamers and trepetania predserdy.

Restrictions on the use of

Violations AV (I) power and vnutrijeludockova conductivity, weakness syndrome sinusnogo hub, heart failure, pregnancy.

Contraindications

Hypersensitivity, AV blockade II and III level (without interference), severe liver failure, terminal kidney failure.

Side-Effects

Headache, dizziness, diplopia, ataxy, hyperemia person tachycardia, электрокардиографиче ские changes : extension PQ interval, widening of Micro; allergic reactions.

Patient interaction

Do effect nedepoliarizuth miorelaksantov.

Precautions

If you have a headache, dizziness, diplopia should be reduced dose. Re-injecting only six hours When sinusova tachycardia against the background of the prolonged reception shown beta-adrenoblokatora (low dose). Appointment of patients with AV blockade I extent syndrome weakness sinusnogo hub and severe heart failure only in a hospital environment with medical supervision and Ekg-controle. Be wary (mainly for health reasons) Designate in the first three months of pregnancy.

Dosing and Administration

Inside, squeezed warm water (tablets should be crushing), in / m, / 386/1989 Inside for 30 minutes before eating, to 0,025 g three times daily, followed by 0.05 g 3-4 times a day with a maximum daily dose and 0.3 in / in slowly for 5 minutes in dose 0,0003-0,0004 g / kg previously razveda in 20 ml of 0.9% solution of sodium chloride. B / m dose of 0.0004 g / kg

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