Trimecaine

Chemical name

2-(Диэтиламино)-N-(2,4,6-тр иметилфенил)ацетамид (as hydrochloride)

Gross

C15-H24-N2-O

Characteristics

White or white with a yellowish sheen crystalline powder. Rat in the water and alcohol.

Of drugs

The drugs-mestnoanestezirutee, antiaritmicescoe. With sufficient lipophilicity, permeates through nerve sheath fibres, has been associated with the receptor and violates the depolarization by blocking the nervous system. Has protiwaritmicescuu activity resulting from the stabilization of cardiomyocytes membranes and inhibition "slow" sodium current. Is exit potassium suppresses automaticity ectopiceskih drivers rhythm, shorter length of the building and effective refrakternogo period.

Indications

Local anaesthesia - superficial, infiltrazionnaya, provodnikova and spinnomozgova; Jeludockove ekstrasistola, tachycardia.

Contraindications

Hypersensitivity, weak sinusnogo hub, AV blockade expressed aetiology, cardiogenny shock liver pathology.

Side-Effects

Hypotension, headache, dizziness, drowsiness, anxiety, noise in the ears, swelling language and mucous membrane cavity, impaired vision, apnoea apnoea, tremor, aetiology.

Patient interaction

Vazokonstrictora increased and lengthened effect.

Dosing and Administration

The surface anaesthesia using 2-5% solution in the branches - 0,125-0,25-0,5% solution for up to 1500-800-400 ml respectively; In the wires - 1-2% solution of 100-20 ml; Spinal 5% solution of 2-3 ml. For short of rhythm being 80-120 mg in a 2% solution at the speed of 2 mg / min.

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