Betalok river

Roman name

Betaloc ZOK

Characteristics

Answers from white to white with a blue-coloured round with a mark of engraved on the other side.

Pharmacokinetics

Absorbed from the intestine entirely, systemic bioavailability-50%. T_1/2 3.5 p (1-9 h). Is oxidative metabolizmu in the liver. More than 95% found in the urine; Of these, only 5% are shown unaltered.

Farmakodinamika

Lowers AD is мембраностабилизирую щее Effects. Decreases consumption miocardom oxygen Frequency attacks in pain and increases tolerance to physical activity. The blockade beta_1-retseptorov providing solid clinical effect is 24 hours

Clinical pharmacology

In postinfarctne period reduces the risk of fatal outcome (including sudden death) and the likelihood of a heart attack recurrence, including in patients with diabetes mellitus.

Indications

Hyperten, stenocardia, of a heart rhythm, especially supraventrikuliarnaya tachycardia; Postinfarknetary period (maintenance therapy), the functional heart disorders accompanied by shortness; Migraine (prevention).

Pregnancy and lactation

Acceptable, but should take into account the possibility bradikardii development of the fetus, a newborn or a child who is breastfeeding.

Contraindications

Hypersensitivity, AV blockade II or III extent expressed sinusova aetiology, symptoms of weakness sinusnogo unit asthma heart failure, cardiogenny shock, the peripheral blood circulation.

Patient interaction

Do negative foreign and dromotroponuu activity complications products and foreign-hronotroponuu calcium antagonists (especially in the on / in the introduction), cardiodepressivnuu-inhalation anesthetics. Indometacin etc. inhibitors простагландинсинтета зы may reduce gipotenzivny effect.

Precautions

Nor should appoint patients with suspected acute myocardial Miocarda.s appoint caution in heart failure (obligatory prevention decompensation), before surgery (to prevent an anaesthetist on the admission of drug), drivers of vehicles and people skills relate to the high concentration (possibly sudden dizziness or weakness). It should not be at the same time / in introducing calcium antagonists. Patients feohromotsytoma further appoint alfa-adrenoblokator. While diabetes may require correction dose oral protivodiabeticakih products in bronchial asthma - бета_2-адреномиметико��. In the case of a joint application with Clonidine, if necessary, repeal of the recommended treatment бета-адреноблокаторо�� , a few days before the clonidine. Gradually abolish (1.5-2 hour), reducing dose and bringing it to 25 mg / day for the past six days. Simultaneous treatment ganglioblokatorami, etc. бета-адреноблокатора��и or MAO inhibitors requires careful medical supervision.

Dosing and Administration

Inside, once a day (preferably morning), regardless of the meal, not liquid, liquid squeezed. In selecting doses, it is necessary to avoid development брадикардии.Артериал��ная Hypertension : the recommended dosage for patients with mild or moderate form of hypertension is 50 mg / day every day, in the absence of therapeutic effect can be increased dose to 200 mg / day or combine with other antigipertenzivei Preparatami.stenocardia : recommended dose is 200 mg, if necessary Betalok ® ones can be combined with other drugs to treat �тенокардии.Стабильна я chronic heart failure, II functional class : Recommended starting dose of the first two weeks-25 mg, after 2 weeks dose may be increased to 50 mg will be able to continue to double in the next two weeks. Task dose for long-term care insurance-200 Mg.stabilnaya chronic heart failure, quite functional class : Recommended starting dose of the first two weeks, 12.5 mg (1 / 2 table). . Dose selected individually. At a time of increased dose of the patient should be kept under supervision, as possibly worsening symptoms of heart failure. After 1-2 weeks dose may be increased to 25 mg. Then after two weeks dose may be increased to 50 mg. Patients who are well shift to higher doses, it can be double the dose every two weeks until the maximum dose of 200 mg. In the case of hypotension and / or bradikardii may require concomitant reduction therapy or dose reduction Betalok ® ones. Gipotenzia early therapy does not necessarily indicate that the dose Betalok ® cartel is transported in further long-term care. However, the dosage should not be increased until the condition stabilizes. There is also a need to monitor the function Pocek.serdecnae adults : Recommended dose-100-200 Mg.funktionale heart disorders accompanied by shortness : recommended dose is 100 mg, if necessary dose can be increased to 200 Mg.prophylactika migraines : recommended dose is 100-200 Mg.net adjust the dose of elderly patients, patients with impaired kidney. Typically, if there is a violation of the liver, including in patients with cirrhosis of the liver, it did not require a dose adjustment. If symptoms of a serious breach of the liver (for example in patients with the disease have been dealing with shuntirovaniem) should consider the possibility of reducing the dose.

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