Fort Fotil

Roman name

Fotil forte

Pharmacokinetics

Pilocarpine well penetrate rogovitsu reaching C_max in watery moisture through 30 minutes. Binds many tissues eye T_1/2 of eyes ranged from 1.5 to 2.5 hours There is metabolized into watery moisture, vdelacy with it. Related timolola appointment, which reduces vnutriglazna liquid reduces speed pilocarpina off. Rapidly hydrolyses in the serum and liver to an inactive form. T_1/2 of plasma, less than 30 Min.timolol quickly permeates through rogovitsu. Inner pressure is reduced from two hours after local application. The maximum effect is achieved through 6700 and whose continued for 10-20 h.

Farmakodinamika

Pilocarpine, stimulating m-holinoretseptora reduces inner pressure by reducing resnicna muscles and muscles iris recognition, resulting in an increase in the angle of the front of the camera eye and alters the physical structure of trabecula tissue, facilitating aqueous outflow of moisture (effect is between 4 and 14 h). Timolol prevents binding simpatomimeticakih with neiromediatorov бета_2-адренорецептор��ми resnicnom in the body, reduces product watery moisture, reducing the inner pressure.

Indications

Otkratougolnaya and zakratougolnaya glaucoma, glaucoma in afakii, secondary glaucoma expressed recovery vnutriglaznogo pressure (in conjunction with other resources), improved vnutriglaznogo pressure after operations on the eye.

Pregnancy and lactation

The drug should not be used during pregnancy and breast-feeding, if the treatment effect is less than the potential risk to the fetus.

Contraindications

Hypersensitivity to any of the components of the drug, acute irit, sinusova aetiology, AV blockade II and III extent cardiac insufficiency of the decompensation, cardiogenny shock, bronchial asthma, chronic obstructive lung diseases in heavy Forme.s caution applied to cerebrovascular disorders, heart failure, bronchial asthma, diabetes and gipoglikemii, tireotoxicose, the operations primenenem general anesthesia.

Specific guidance

Not to be applied in conjunction with other PP containing бета-адреноблокаторы. Использование other eye drops should be terminated before the start of drug treatment. Previous antiglaucomnoe is to be lifted and therapy eye drops Fotil begin from the next day. The effectiveness of treatment should be conducted in the four weeks after the start of treatment (some patients in a few weeks there is a growing толерантности).Лечени е carried out with regular monitoring vnutriglaznogo pressure.

Patient interaction

Products that violate deposit catecholamines (rezerpin) contribute to the development of arterial hypotension (including Orthostatic), and bradikardii головокружения.Однов��еменное the �ета-адреноблокаторов �istemnogo actions resulted in the consolidation of their pharmacological effect.

Precautions

Timolol permeates through GEB has an impact on the central nervous system, especially in cases of overdose. Older patients with heart failure in history can be observed : asteniceski syndrome, vomiting, dizziness, anxiety, hallucinations, headache and depression; Less-zalojennosti nose, diplopia, Ptoz.nescolco cases otslaki retina, rigidity radugki or cyst formation of the iris have been marked by the use of mioticeskih funds. Forming plastic aphykia prevailed in the long Pilocarpina.simptoma contact allergies and allergic dermatitis skin century were in therapy preparations containing pilocarpine. In patients with a heightened sensitivity to timolol maleatu may appear skin, urticaria, or allergic блефароконъюнктивит.��иск Development of tolerance combined drops lower than in the application of preparations containing only one active Veschestvo.neobhodimo be careful when driving at night or in bad Osvetmeni.pered zacapavaniem should remove contact lenses and re-establish it in 15 minutes after the application �репарата.Безопасност ь and effectiveness in children has not been established.

Storage conditions

List B. The temperature 2-8 ° C. Open-bottles at room t (below 25 ° C), in the dark place

Shelf life

3 years. After opening bottle-1 month

The registration

015333/01

The drug forms

Transparent slightly gorkovataya, colorless liquid watery odourless.

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