Directory → Organotropona funds → Cardiovascular funds → Beta-adrenoblokatora → Lokren
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LokrenSee also BetaxololRoman nameLokrenPharmacokineticsQuickly and completely absorbed, bioavailability is about 85%, tying with the plasma protein-50%, the volume of distribution-6 l / kg Active metabolites retain cardioseleguosti, most of the active metabolites. 10-15% return with urine in an unmodified form, T_1/2 is 15-20 hrs,FarmakodinamikaCardioselegus adrenoblokada at concentrations exceeding industry, coupled with weak мембраностабилизирую щим (hinidinopodobnam) effect. There has cardiodepressive effects (in therapeutic doses), does not influence the metabolism of carbohydrates, lipids, sodium excretion.IndicationsArterial hypertension, preventing strokes voltage.Pregnancy and lactationApplication of pregnancy is possible only when a benefit to the mother outweighs the potential risk to the fetus and / or child. At the time of treatment should stop breastfeeding.ContraindicationsГиперчувствительност ь. Its chronic heart failure, cardiogenny shock Av-blokada II and III level in the absence of the driver artificial heart rhythm, stenocardia Prinzmetala, weakness syndrome sinusnogo node (including sinoatrialnaya blockade), aetiology (less than 45-50 u. / min). A caution : Reynaud syndrome, heavy human peripheral blood circulation, bronchial asthma, severe obstructive lung diseases, feohromotsytoma, in the absence of treatment; Combination therapy with floktafeninom and sultopridom in Practice (relative).Side-EffectsSeven (early treatment), parestesia, Reynaud syndrome, aetiology, Av-blokada, gipotenzia, heart failure, bronhospazm, skin diseases (psoriazopodobne), the syndrome.Specific guidanceCancel 48 hours before narcosis sufficient to restore sensitivity to kateholaminam. The diabetics there is a need to increase the content of the glucose in the blood, especially at the beginning of treatment.Patient interactionSultoprid and antiaritmicescie drugs (amiodaron, diltiazem, verapamil, hinidinove drugs Ia class) increased the risk of violations of automaticity, and conduction sokratimosti heart. Combining with digidropiridonovmi BAC in patients with latent heart failure increases the risk of hypotension and cardiac decompensation activities. It may be possible to reduce compensation cardiovascular reactions in response to the use of inhaled anesthetics AC and floktafenina, masking symptoms gipoglikemii (tachycardia, palpitations), in patients with diabetes taking insulin or other gipoglikemicakie drugs. NPVS and steroids, and obwolakiwate antatsidnye to weaken gipotenzivny effect; Tricyclic antidepressants (imipramin) increase (can cause ortostaticescuu hypotension).PrecautionsBe wary appoint patients with heart, kidney or liver failure, chronic bronhoobstruktive syndrome, I Av-blokada extent feohromotsytoma and diabetes receiving antiaritmiki, BAC, imipramin. Remove admission should gradually (risk secondary sympathetic hyperactivity).Storage conditionsList B. In dry place at a temperature below 25 ° CShelf life5 yearsThe registration012715/01 |
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