Metokard

Roman name

Metocard

The composition and the form of

1 tablet (Metokard) contains metoprolola tartrate 50, or 100 mg; in polypropylene bottles or vials dark glasses to 30 pcs. , in a cardboard bundle one bottle or contour F9 packages to 10 pcs. , in a cardboard bundle three upakovki.1 tablet (Metokard retard), 200 mg; in a contour acheikova packing 10 pcs. , in a cardboard 3 bundle packaging.

Pharmacokinetics

Quickly and almost completely absorbed from the digestive tract. C_max T_max and to the reception Metokard 100 mg or retard Metokard of 99.4 ± 33 ng / mg and 1.58 ± 0.55 h or 152.9 ± 72.8 ng / ml and 2.75 ± 0.87 h Linking protein-11-12%. Metabolised in the liver T_1/2-3.5 hours Excreted in the kidney (95%). Passes through the placenta.

Farmakodinamika

Decreases inner volume and the heart. Oppressing central impulsaciu sympathetic. Has no мембраностабилизирую щего actions and has no internal simpatomimeticescoy activity.

Indications

Arterial hypertension, stenocardia (preventing attacks), and violations of heart rhythm, including najeludochkovaya tachycardia, arrythmia (except Metokard retard).

Pregnancy and lactation

Perhaps during pregnancy, if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, AV blockade II and III level, the acute cardiac insufficiency, sinoaurikuliarnaya blockade aetiology Arterial gipotenzia, chronic heart failure IIB-III stage cardiogenny shock later stage, and serious violations of peripheral blood circulation, the simultaneous appointment of MAO inhibitors, intravenous blocking calcium channels (verapamil, diltiazem), or other complications of funds (dizopiramid), breast-feeding.

Patient interaction

Do gipoglikemicescoe of insulin and oral protivodiabeticakih preparations cardiodepressivny anaesthesia effects and complications of deprimiruty-alcohol. Zimetidin increases concentration in the blood, rifampicin - lowers. Heart glycosides increase likely bradikardii, rezerpin, verapamil and other calcium antagonists, of the heart rhythm and hypotension, derivatives ergotamine-disorder peripheral blood circulation.

Precautions

Be wary apply diabetes, human peripheral blood circulation, including rheumatoid Reynaud, feohromotsytome, heavy violations of the kidneys and liver, bronchial asthma, bronchitis obstruguom, gipertireoze, extended golodanii, azidoze, in patients in old age. It should refrain from the use of Metokarda retard in paediatric practice (safety and efficiency to be determined). There is a need to lift the 48-72 hours before delivery (there is a growing bradikardii and hypotension in the offspring). Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention.

Storage conditions

List B. In a dry, the dark place at a temperature of no higher than 25 ° C

Shelf life

3 years

The registration

013293/01-2001

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