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Nebilet

See also Nebivolol

Roman name

Nebilet

Characteristics

Cardioseleguy beta_1-adrenoblokator.

Pharmacokinetics

After intake of rapidly absorbed from the gastrointestinal (eating no influence on the skin). Bioavailability 12% of those with the "fast" metabolism (effect "of a" through the liver) and the almost total-for persons with the "slow." Relations with the squirrels for D-nebiwolola - 98.1%, for L-nebiwolola-97.9%. Metabolized with the formation of active metabolites by acyclic and flavour gidrauxilirovania and partial N-dealkilirovania; Formed hydroxy-and aminpirizvodona kongugiruut with glukuronova acid, and displayed in the form and containing N-glukuronov. T_1/2 gidroximetabolitov-24 hour enantiomers nebiwolola-10 hrs (for those with fast-metabolism); For the "slow" - 48h and 50 h respectively. Report the news (38%) and gastrointestinal (48%).

Indications

Arterial hypertension, ischemic heart disease.

Pregnancy and lactation

When pregnancy and breastfeeding should be used with caution on strict conditions, under the supervision of a physician.

Contraindications

Hypersensitivity, bronchial asthma, heart failure (under decompensation), serious violations of the liver, blood gipotenzia expressed aetiology, cardiogenny shock syndrome weakness sinusnogo hub, AV blockade II and III extent feohromotsytoma, stenocardia Prinzmetala, depression, obliterirute of peripheral vessels ( "peremejatayasa" limp), male, muscle weakness, age and 18 years of age (elapsed, and security is not established).

Side-Effects

Headache, dizziness, fatigue, paresthesia (frequency 10%), nausea, dry mouth, diarrhea or constipation (more than 1% of cases). Aetiology, ortostatical gipotenzia, cardiac failure, oedema, the rhythm of the heart, Reynaud syndrome, AV blockade cardialgia, depression, the loss, drowsiness, insomnia, nightmares, dreams, hallucinations, allergies fotodermatos, rash, bronhospazm (including, in the absence of prior obstructive lung diseases), rhinitis.

Specific guidance

Patients using contact lenses, it should be borne in mind that, against the background of drug treatment may reduce production slezna Jidkosti.nebilet ® recommended for use in people with hypertension, a disease I being accepted for flight practice.

Patient interaction

Combining with anestezirutmi substances is cardiodepressivny effect and increases the risk of arterial hypotension. By using the hypotensive means nitroglitzerinom, blokatorami "slow" calcium channels can develop severe arterial gipotenzia (special caution should be exercised when combined with prazosinem); With antiaritmicakimi means rezerpinom, alfa-metildopoy, Clonidine, guanfationom increase bradikardii symptoms; With cardiac glycosides - summation chrono and dromotroponogo effect; Clonidine with increased syndrome lifting. " Inductive mikrosomalnogo oxidation (rifampicin, barbiturates) away, and inhibitors (zimetidin) to the concentration in plasma.

Precautions

In patients with stroke discontinue therapy should be phased-in within 1-2 weeks. When strokes voltage recommended dose should provide HR at rest within 55 to 60 times per minute, with a load of no more than 110 times per minute. The smokers the drug below. Be wary when using kidney failure in older age (over 65 years), diabetes (possible masking signs of lowering glucose in the blood, nervousness, drugs, rapid heartbeat), and hyperthyroidism (false numerical increase), with a propensity to allergies (possibly increasing anaphylacticakih reactions). The minutes shall only after a thorough analysis of the relationship between the possible risks and benefits of the use of Preparata.monitoring patients receiving medication include monitoring curves and AD (early admission day, and then every 3-4 months), the blood glucose in patients with diabetes mellitus (1 every 4-5 months) renal function in elderly patients (every 4-5 months), of flaccid �ровообращения.Лечени е pregnant to interrupt for 48-72 hours before delivery. If this is not possible, have to be carefully monitored newborns within 72 hours after delivery (perhaps bradikardii development, arterial hypotension, gipoglikemii, paralysis breathing in newborns).

Storage conditions

B. List in a cool and dry place so that the temperature does not exceed 25 ° C

Shelf life

2

The registration

011417/01-1999

The drug forms

Today, dvoyakovpuklae legkodelimae tablets almost white with one Kołki for fission.

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