Izoptin sr 240

Roman name

Isoptin SR # 240

The composition and the form of

1 tablet coated films coated with a slow-release, contains verapamila hydrochloride 240 mg; blistere in 10 pcs. , in box 3, or 10 blisters.

Of drugs

Gipotenzivne, antianginalnoe, antiaritmicescoe, sossoudorasshiratee. Does calzieve channels.

Pharmacokinetics

Quickly and completely (90-92%) absorbed in a thin leg. Almost all metabolised. T_1/2 after a single admission ranges from three to seven hours (with multiple-increased by 2 times). Write mainly kidneys (intestinal about 16%). Passes placental barrier, enters the breast milk (in small quantities).

Indications

Arterial hypertension (light, moderate and severe).

Pregnancy and lactation

The caution (especially in the first trimester).

Contraindications

Cardiogenny shock oslojnenny acute myocardial infarction (events bradikardii, hypotonia, levojeludockova deficiency), AV blockade II extent sinoatrialnaya blockade syndrome weakness sinusnogo hub.

Side-Effects

Heart aetiology, sinoatrialnaya blockade asistolia, AV blockade aetiology and hypotension; Heart failure, dizziness, headache, weakness, block, irritability, parestesia, nausea, constipation, swelling, artralgia, mialgia, tides, allergic reactions.

Patient interaction

Do beta-adrenoblokatorov effects, inhaled anaesthetics antiaritmikov, miorelaksantov. Potenziruet gipotenzivny effect etc. antigipertenziveh funds neirotoksicescoe the carbamazepina drugs and lithium. The plasma reduce rifampicin, phenytoin, and phenobarbital. Zimetidin increases.

Overdosing

Symptoms : hypotension, shock, loss of consciousness, AV blockade I and II of the full AV blockade AV rhythm in the rain sinusnogo unit asistolia, sinusova aetiology, sinoatrialnaya Blokada.lechenie : washing stomach, induction of vomiting, sucking stomach contents and intestines endoskopiceski under control, clean enema. As a specific antidote, in / in 10-20 ml of 10% solution of calcium glukonata, if necessary repeat or carry out additional capelnuu infuziu (5 mmol / h).

Precautions

Be wary appoint the AV blockade degree I (bradikardii less than 50 strokes per minute), hypotonia (Sad below 90 mm Hg), oils, trepetanii predserdy while a syndrome of premature ventricular institute, heart failure (prior to the treatment necessary to compensate the state for cardiac glycosides). It should not be combined with on / in the introduction бета-адреноблокаторо��.

Dosing and Administration

The inside is not liquid, during or after delivery, squeezed small amounts of liquids, 240-360 mg (dose eight individually). With long-term therapy daily dose should not exceed 480 mg. Usually appoint morning on 240 mg. If you want to slow the decline AD designate 120 mg.

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