Lacidipine

Chemical name

4-[0-[(E)-2-Карбоксивинил]��енил]-1,4-дигидро-2,6-дим етил-3,5-пиридиндикарб��новой acid 4 -трет-бутилдиэтиловый �fir

Gross

C26-H33-N-O6

Characteristics

Blokator calcium channels from the group digidropiridina derivatives.

Of drugs

The drugs-gipotenzivne, sossoudorasshiratee. Selectively blocks the flow of calcium ions across potencialzawisimae calzieve channels (mainly L-tipa) smooth muscle receptacles shortened the opening of the channel, reduced transmembranny calzievy current and the concentration of calcium in cells. Increase peripheral arteriola reduces round and reduces AD. It violates the automatic sinoatrialnogo hub, the institute through the AV node, not oppressing airway diseases. It oppresses the skeletal muscles. In patients with liver failure is more pronounced antigipertenzivny Effect.bystro and completely absorbed from the digestive tract. Absolute bioavailability after intake of about 10% dose, the effect of passing "through the liver. C_max achieved through 30-150 min. Associated with the protein (mostly albuminom and альфа_1-гликопротеино��) to 95%. Biotransformiroetsa education low metabolites. T_1/2 is 13-19 hrs, Place in the form of metabolites through the intestine (70%) and kidneys. Latsidipin and its metabolites infiltrating breast milk. There has teratogenic properties.

Indications

Arterial hypertension (monotherapy or in combination with other means).

Restrictions on the use of

It should refrain from the use of drugs in paediatric practice, since safety and efficacy of their use in children has not been quantified.

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus. It should be borne in mind the possibility of relaxing Oxytocics during childbirth.

Contraindications

Hypersensitivity, aortalny stenoses, the period within 1 month after myocardial infarction.

Side-Effects

From the circulatory system and blood (blood, gemostaz) : heartbeat, increased pain (often in patients with ischemic heart disease and early treatment). From the nervous system and sensory organs : the worsening mood, headache, dizziness, rarely man, Sudorogi.so the urogenital system : poliuria, Oteki.so part of the intestine : rarely nausea, neuralgia, dysfunction Jeludka.so the Skin : seldom-skin skin (including erythema), Zud.prochie : rarely giperplazia gums, tides, forming increased alkaline phosphatase.

Patient interaction

Dr. gipotenzivee drugs increase (adaptation) therapeutic and side effects. Alleviate ingibirutee of cyclosporine speed clubockova filtering. Zimetidin slows down. Grapefruit juice reduces the bioavailability and metabolism. Compatible with beta-adrenoblokatorami, dioretikami, digoxinom, tolbutamidom, varfarinom.

Precautions

There is a need for caution in patients with pulmonary drivers rhythm, lower heart emission unstable stroke, liver failure and early postinfarctne period.

Dosing and Administration

Inside, in the morning, at the same time, regardless of the meal. At the beginning of treatment to 1 mg / sut. After 3-4 weeks dose can be increased to 4 mg / sut. Take preparation can be an indeterminate amount of time.

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