Nicardipine

Chemical name

Метил-2-[метил(фенилме��ил)амино]этил-1,4-дигид ро-2,6-диметил-4-(3-нитро��енил)-3,5-пиридиндикар��оксилат (and as hydrochloride)

Gross

C26-H29-N3-O6

Characteristics

Sulphur crystalline powder, odourless. Easily soluble in chloroform and methanol, soluble in ethanol, poorly soluble in water, butanole and acetone.

Of drugs

The drugs-gipotenzivne, antianginalnoe. In zitoplazmaticescoy membrane selectively blocks calzieve channels (and violates their education) for incoming currents slow calcium ions and reduced Intracytoplasmic содержание.Биодоступ��ость - about 35%. Connectivity protein plasma high-more than 95%. C_max and greatest manifestation of the highlights in 1-2 hours, the duration of effect until 8 am Treated biotransformation in the liver with the formation of active metabolites. T_1/2 two-phase : initial phase 2-4 hour terminal - 8.6 hours Report : 60% of kidney (only 1% of the active form), and 35% кишечником.Расслабля��т gladkomyshechne cells vascular wall is arterial pressure, which leads to expansion, reduce CSO, reduce systemic AD. In response to the downgrading of peripheral resistance can cause tachycardia fence. Improves blood brain and coronary flow increases perfuziu ishemizirovanna in the attack. There is a significant impact on the conductivity and airway diseases. Provides antiagregatine effect by reducing the calcium in platelets.

Indications

Arterial hypertension, stenocardia voltage vazospastical stenocardia.

Contraindications

Hypersensitivity, arterial hypotension, aetiology, heart failure, myocardial infarction, cardiogenny shock, renal and hepatic failure, prostate adenoma gland.

Side-Effects

Reddening and feeling tidal blood to a person, headache, dizziness, refers, fatigue, drowsiness, arterial hypotension, stenocardia, tachycardia, heart failure, peripheral oedema, diarrhoea events (nausea, vomiting), xerostomia, atony bowel and bladder, allergic reactions.

Patient interaction

Do the gipotenziveh funds dioretikov, antiagregantov, anticoagulants, as well as side effects beta-adrenoblokatorov, cardiac glycosides, hinidina, procainamide, estrogen. Simpatomimetiki reduce effectiveness.

Precautions

During treatment should refrain from potentially dangerous activities requiring attention. There should be no use of alcohol. As there is no information on the safety of the pregnant and lactating women, as well as to children who required careful in appointing nikardipina these categories of patients.

Dosing and Administration

Inside, in the mean dose of 20 mg 2-3 times a day.

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