Normodipin

Roman name

Normodipine

The composition and the form of

1 tablet contains amlodipina 5 mg (in the form of 6.944 mg amlodipina bezilata), or 10 mg amlodipina (in the form of 13.889 mg amlodipina bezilata), as well as magnesium stearate, карбокси-метил-амилоп ектин-А sodium gidrofosfat calcium mikrochristallicescuu pulp; conwalute in 10 pcs. , in box 3 conwaluta.

Of drugs

Antianginalnoe, gipotenzivne. Does calzieve channels, hampering the flow of calcium ions in and cardiomiotita gladkomyshechne cells receptacles.

Pharmacokinetics

Once inside well, but slowly absorbed from the intestine of mealtimes. C_max is six hours Bioavailability of 63 to 80%. Linking plasma protein-95-98%. Bioavailability of 63 to 80%. The distribution of approximately 20 l / kg In permanent employment equilibrium concentration in the plasma created within 7-8 days. Biotransformiroetsa in the liver with the formation of active metabolites. T_1/2 - 35-50 h. News presented as a metabolites (60%) and unaltered (10%).

Farmakodinamika

Impact tone smooth muscles arteriol reduces round, postnagruzku on the heart and the need heart of oxygen. Increase coronary vessels (arteries and arteriola), including : in ishemizirovannah stations. Thanks to a slow start, and the effect prolongirovannomu a gradual decline AD.

Indications

Essential hypertension (mono-and complex therapy), a stable stenocardia, stenocardia Prinzmetala.

Pregnancy and lactation

Perhaps the only absolute condition if the expected benefits of therapy outweighs the potential risk to the fetus (security application during pregnancy and lactation has not been established).

Contraindications

Hypersensitivity, the children's age (safety and efficacy of the application of non-identified).

Side-Effects

From the nervous system and sensory organs : headache, dizziness, fatigue, drowsiness, and rarely fatigue, mood changes, visual Rasstroistva.so the circulatory system and blood (blood, gemostaz) : Serdzebienie.so the respiratory system : rarely Odyshka.so part of the intestine : nausea, pain in the abdomen, rarely neuralgia, giperplazia gums, very rarely change in the level of liver enzymes Jeltuha.so the urogenital system : oedema, rarely increases in the frequency of urination, Impotenzia.so the musculoskeletal system : rarely artralgia, Mialgia.so the Skin : hyperemia skin, rarely skin rashes, skin itch, multiformnaya Eritema.prochie : rarely ginekom 1c6c5 astia.

Patient interaction

Compatible with tiazidnami dioretikami, beta-adrenoblokatorami, enzyme inhibitors, nitrates, NPVS, antibiotics, oral противодиабетическим и drugs.

Overdosing

Symptoms : excessive peripheral vazodilatation expressed and prolonged decline Ad.lechenie : washing the stomach, giving patients the horizontal position with pripodnatami feet, monitoring the performance of the heart and lungs, control and BCC diureza; Symptomatic and supportive therapy, in / with the introduction of liquids glukonata calcium. Haemodialysis ineffective.

Precautions

Be wary designate if there is a violation of the functions of the liver.

Dosing and Administration

Inside, every day, the initial dose of 5 mg, if necessary, increase the dose to the maximum (10 mg / day).

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