Directory → Organotropona funds → Cardiovascular funds → ACE inhibitors
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The groupIn modern standards of treatment of hypertension and chronic heart failure one of the leading places are inhibitors ангиотензинпревращаю щего enzyme (Iapf). Currently, there are dozens of chemical compounds that can block transition angiotenzina I biologically active angiotenzin II. With long-term therapy the PP a lower round, and the post at prednagruzki miocard, declining Sad and Dad, Reducing filling pressure left chamber, reducing the frequency and jeludockovh reperfuzih arrhythmias, the improvement Regional (coronary, cerebral, renal, muscular) blood circulation.
Cardioprotectivei effect the prevention and the development of self-isolationist and dilatation of the left heart chamber, the improvement diastolicescoy the heart, weakening of cardiac fibrosis and heart remodelirovaniem; angioprotectivei-prevention hyperplasia and proliferation gladkomyshechnykh cells opposite of hyper smooth muscles coronary artery walls. Антиатеросклеротичес кий benefits realized from the education system on the surface of cells endotelialnah angiotenzina II and the education nitrogen oxide.
The therapy Iapf increased sensitivity peripheral tissues to the action of insulin, improving glucose metabolism (due to the increased level bradikinina and improving circulation). Due to the reduced production and the release of aldosterone napochechnikov growing diurez and natrillurez, increasing potassium normal water metabolism. The pharmacological effects is the impact on fat, carbohydrate and purinovy exchange.
Side-effects associated with the use of Iapf include gipotenzia, diarrhoea phenomenon of taste sensations, paintings peripheral blood (trombopenia, lakopenia, neutropenia, anaemia), skin rashes, swelling angioneuroticeski, cough, etc.
Outlook is a further study of pharmacological action Iapf in conjunction with the definition of peroxide oxidation of lipids, of antioxidant system and eikozanoidov levels in the body.