Captopril-egis

Roman name

Captopril-Egis

The composition and the form of

1 tablet contains Captopril 12.5, 25, 50 or 100 mg; blistere in 10 pcs. , in box 2 blisters.

Of drugs

Gipotenzivne. Ingibiruet agents and making angiotenzina I angiotenzin II, the collapse of bradikinina reduces force on resistance, pre - and the postnagruzku miocard.

Pharmacokinetics

Quickly and almost entirely (75%) of the skin glands. Joint reception with food absorption decreases by 30-40%. Associated with the plasma protein to 25-30%. C_max plasma achieved through 1hr Passes through gistogematicalkie barriers (excluding GEB), crosses the placenta. Treated biotransformation in the liver. T_1/2 Captopril, 45-120 min, its metabolites, 9-12 pm Excreted mainly kidneys (75%), as in the form of metabolites, and the unmodified form (50%). During the 24 hours to return 95% vsosavchegosa preparation. In violation of the kidney may koumoulirovati.

Indications

Arterial hypertension (essencialnaya, renovskularnaya, malignant), female heart failure, cardiomyopathy, to slow progression of nephritis and nefropatii diabetes, differential diagnosis when renovskularna hypertension and rheumatoid Conna.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, lakopenia, anaemia, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : headache, insomnia, paresthesia, Laringospazm.so the circulatory system and blood (blood, gemostaz) : ortostatical gipotenzia, tachycardia, palpitations, cardialgia, neutropenia, Agranulozitoz.so part of the intestine : anorexia, dry and metallic taste in the mouth, afta mucous membranes of the oral cavity, neuralgia, the increase in the liver Transaminaz.prochie : azotemia, giperkaliemia, proteinurija, psevdopolojitelnaya reaction to acetone in the urine.

Patient interaction

Incompatible with kalisberegatmi dioretikami. NPVS weaken therapeutic activity.

Dosing and Administration

Inside for 1 hour before meals. In heart failure initial dose for 6.25 mg 2-3 times a day. In hypertension initial dose, 12.5 mg three times a day with a gradual increase in the need for up to 50 mg three times daily. The maximum daily dose is 300 mg, with the lack of gravity gipotenzivnogo actions combine with other drugs. In patients with renal insufficiency require a daily dose : if Cl creatinine 40-21 ml / min / m ^ 2, and 150 mg, 20-11 ml / min / m ^ 2 to 75 mg, less than 10 ml / min / m ^ 2 to 37.5 mg.

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