Breinal

Roman name

Breinal #

The composition and the form of

1 tablet coated liner nimodipina contains 30 mg; blistere in 10 pcs. , in box 3 and 10 blisterov.50 ml for in / infusions of 10 mg; Patients in the dark glass of 50 ml, in the box one bottle.

Of drugs

Sossoudorasshiratee, neiroproteguoe, antianginalnoe. Selective blokator calcium channel II class.

Pharmacokinetics

The ingestion drawn from blood, bioavailability of 12% (in patients with bleeding subarahnoidalnam to 16%). C_max when administered through the 0.5-1 h, and on / in the introduction, through 1999. Linking blood plasma proteins from 95 to 98%. Metabolised in the liver, displayed with faeces and urine. T_1/2 8-9 hrs (increasing expressed in liver failure).

Farmakodinamika

Selectively influence on vessels in the brain that helps to reduce neurological violations zerebrovskulyarnogo genesis. Contraktilnosti reduces smooth muscle pressure, particularly brain, which leads to arterial vazodilatace and reduce peripheral resistance. Expanding coronary vessels, increases in blood flow. Several reduces airway conductance and heart.

Indications

Neurological disorders as a result of acute cerebrovascular caused bleeding subarahnoidalnam (prevention). Acute cerebral ischaemia (early therapy). Neurological symptoms associated with the process of ageing (impaired memory, emotional instability, a decline Initiative).

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus.

Contraindications

Brain swelling expressed vnutricerepnogo increasing pressure Hypersensitivity to the drug component.

Patient interaction

Do effect etc. gipotenziveh funds beta-blokatorov (possibly increasing negative inotropongo of decompensation and heart failure). Increases the risk of kidney failure in the face of potentially nefrotoksicskih preparations (aminoglikozidov and / or zefalosporinov, furosemida).

Overdosing

Not there. However, in these cases, should monitor the cardiovascular system, a simptomaticescuu therapy, including the use of gipertenziveh funds.

Precautions

With the utmost care to appoint oteke brain and increased vnutricerepnom pressure. Be wary, with the liver disease, alcoholism, epilepsy, children, the solution for the infusions of ethanol. The dramatic drop in AD or when severe headache treatment should cease immediately. In patients with renal insufficiency to special monitoring kidney functions, in the case of deterioration of the treatment should be terminated. If absolutely combination with other calcium antagonists or metildopa requires special monitoring of the patient's condition. Do not engage in activities requiring concentration and reaction speed in the first weeks of therapy.

Dosing and Administration

At the beginning of therapy in / in infuziruut 1 mg (5 ml r-ra d / inf.) for 2 h at 15 µ g / kg / h, in the case of good endurance and Lasting AD dose increased to 30 µ g / kg / h (2 mg to 10 ml r-ra d / inf.); patients weighing less than 70 kg or unstable AD should start with 0.5 mg (2.5 mL r-ra l / inf. Q / in the introduction should start no later than four days after the bleeding and continue throughout the duration of increased risk of vazospazma (within 14 days after subarahnoidalnogo bleeding). After infuzionna Therapy Brienal appoint inwards. If surgical removal of the causes of gemorragii in / in the introduction to not less than 5 days after the operation. Introduction to the brain jeludocki : 20 ml divorced solution containing 1 ml for drug infusions and 19 ml Ringera.vnutri pills to swallow are not liquid, squeezed few Jidkosti.pri ishemicescom stroke recommended initial dose 30 mg (1 tab). four times a day at intervals of 6900, duration of treatment is not more than 1 Mes.dla prevention of ischaemic neurological disorders in spazme of the brain as a result of bleeding subarahnoidalnogo (after prior to / therapeutic solution for the infusions during 5-14 days) appoint 60 mg (Table 2.) 6 times a day for up to 7 days. The interval between meals is not less than 4 C.pravila the drug : in / in cefuroxim constant and prolonged carried out using infuzionna film, along with the infusion solutions, blood or plasma products through the central catheter. To ensure an adequate separation nimodipina imperative that imposed the amount of fluid was not less than 1000 ml / sut. Since nimodipin absorbed PVC should only use polyethylene infusion tube. The recovery protect skin, and pump infusion tube from the light non-transparent tissues, or use syringes and infusion tubes black or brown. The spread light or artificial light solution can be stored without protection for a period of 10 hours is not recommended to use interrupt nimodipina in anaesthesia, surgery and angiography. When surgery divorced solution give jeludocki brain at room temperature.

Storage conditions

r-r d / inf. : List B. In safe from direct sunlight place at room temperature. Cooked prevailing solution is to be protected from sun svetatabl.p.o. : List B. At room temperature

Shelf life

r-r d / inf. : 2 g.tabl.p.o. : 3 and

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