Nicergoline

Chemical name

(8бета)-10-Метокси-1,6-дим етилэрголин-8-метанол�� 5-brom-3- piridincarboksilat (ether)

Gross

C24-H36-Br-N3-O3

Characteristics

White or slightly yellowish white crystalline powder. Virtually nerastvorim in water, soluble in alcohol.

Of drugs

The drugs-alfa-adrainoliticescoe, miorelaksirutee, sossoudorasshiratee. Provides complex impact of the receptacles. Ergolinova group provides альфа-адреноблокирую��ее effect, which leads to vazodilatace and improve circulation. Balance nicotinic acid ability to directly undermine muscle sheath resistance receptacles (remove patients), makes them easy to glucose. Nowhere was this effect is against cerebrovascular and limbs. It absorbed in the digestive tract. Bioavailability is about 60%. C_max is 2-4 hours Treated biotransformation in the liver with the formation of active metabolites. Excreted in the faeces with.

Indications

Atherosclerosis cerebrovascular, the cerebral circulation, vertigo, migraine, obliteriruty endarteriit illness Reynaud, diabetic and retino- angiopatia, dystrophic diseases of cornea, heart failure visual stimulus, the peripheral blood circulation.

Restrictions on the use of

Pregnancy. There is no information on the safe use of the breast-feeding women and children.

Contraindications

Hypersensitivity, arterial hypotension expressed arteriosclerosis peripheral vessels, organic heart failure, myocardial infarction, stenocardia voltage.

Side-Effects

Diarrhoeal phenomenon : nausea, vomiting, diarrhoea, pain in the abdomen; Sleeping, hypotension, headache, dizziness, stroke, the symptoms ergotizma, cooling off, the pain and disruption of limbs, skin and hyperemia individuals and the top half of the body, allergic reactions.

Patient interaction

Do effects gipotenziveh funds. Simpatomimetiki in sharing could cause idyoshinkraziu. Antatsida and holestiramin slow induction.

Dosing and Administration

Adults, inside-to 10 mg three times a day before meals. The course of treatment is at least 2 months.

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