Directory → Organotropona funds → Cardiovascular funds → Nitrates and the nitratopodobne
This page is translated automatically with a help of Google Translate
Nitrates and the nitratopodobne
The groupOrganic nitrates are widely used as a means antianginalnah used in the most common heart disease : disease, strokes, Myocardial infarct etc. Nitrosodergaszczye compounds improve blood circulation and metabolism diseases, influencing pathogenetic parts of the cardiovascular diseases. The basis of their effects on the ability of substratno increase of nitrogen oxide.
The representatives of the organic nitrates are nitroglycerine and nitrosorbid (mono-isosorbide dinitrate and). Recently, a special dosage forms nitrate prolonged action (nitrogranulong, sustak, nitrong etc.), polymeric film, containing nitrates (trinitrolong, dinitrosorbylong).
Medicinal nitroglycerin have miotroponam spasmolytic activity and directly rasslablaut muscle coronary. A role in the mechanism of action of nitroglycerin is its central inhibitive effect on Stroke sympathetic tone. Antianginalny effect of nitroglycerin by the restructuring hemodynamics related to the common sossoudistam by drug rasslableniem influenced by smooth muscle peripheral vessels, in particular with its venodilatirutm influence.
Influenced nitroglycerin decreases venous blood flow to the heart, reducing pressure in the right predserdii, in the pulmonary artery and the reduced force on vascular resistance. As a result of nitroglycerin was unloading attack, it reduces the voltage to overcome resistance to the release of blood decreasing its oxygen demand and energy costs. There has been reduced cardiac stress contributes to the restoration of blood flow in small vessels heart, the blood flow in epikardialnah coronary arteries. Together with the reduction Cerebral gradually disappears sensitive impoulsation ishemicski from home and terminates pain syndrome.
The nitrate is not limited impact on coronary vessels, they are the other blood vessels (of the brain, peripheral vessels, receptacles abdomen).