Bencyclane

Chemical name

N,N-Диметил-3-[[1-(фенилме тил)циклогептил]окси]- 1-пропанамин (and in the form of fumarata)

Gross

C19-H31-N-O

Characteristics

White TNT substance odourless. Not soluble in water, it was easy to alcohol.

Of drugs

Drugs, the skin, sossoudorasshiratee. Impact tone and motor activity of smooth muscles of internal organs. The ingestion quickly and almost completely absorbed. C_max in blood after a single reception is for the first 3 hours T_1/2 6 p.m. Intensive be biotransformation. 97% excreted in the urine in the form of inactive metabolites. Along with the spazmoliticescoy sedativna moderate and weak mestnoanesteziruta activity. Virtually no effect on AD.

Indications

Violations of cerebral circulation, cerebrovascular disease and ateroskleroticski angiospasticski genesis, vascular disease eye disease central retinal artery, diabetic angiopatia, obliterirute of peripheral arteries of different genesis, angiodistonia, and the post-traumatic human peripheral blood circulation, variantnaya stenocardia, saying disease stomach and duodenal ulcers, other gastrointestinal diseases accompanied by spasticescoy or gipermotorna diskineziei oesophagus, stomach, Pepsi ways, intestine and kidney kolica, cramps urinary tract, bronchoobstructive syndrome.

Restrictions on the use of

Adenoma prostate cancer in violation of urine outflow. For injecting the loss of the cardiorespiratory system, the propensity to kollapsam.

Contraindications

Renal failure expressed by the human liver, respiratory distress, tahiaritmii.

Side-Effects

Dizziness, headache, general weakness, arousal, sleep disturbance, tremor, epileptiformnye symptoms, hallucinations, dry mouth, nausea, anorexia, diarrhoea, transient increase in liver transaminaz, tachycardia, lakopenia. Sometimes human kidney function.

Patient interaction

Do deprimatia caused narkoznami and sedatives. Increase the likelihood of tachiarrhythmia against simpatomimetikov risk oppression heart activity under the influence of drugs kaliwavodath (dioretiki, corticosteroids).

Overdosing

There hypotonia, psychomotor Vozbujdeniem.lechenie : symptomatic.

Precautions

In Injecting a recommended change of use (to prevent tromboflebitov). With long-term use should be systematic monitoring of liver function and general blood tests. Together with the appointment of drugs causing gipokaliemia, cardiac glycosides, cardiodepressantami, daily dose should not exceed 150 mg.

Dosing and Administration

Inside on 100-200 mg 1-2 times a day for 3-4 weeks, then 100 mg twice a day (maintenance therapy); Maximum daily dose is 400 Mg.pri acute and serious diseases over appoint dropped on 100 mg 1-2 times a day, in / in slow struino (physiological solution), or m-50 mg 1-2 times a day.

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