Drotaverine

Chemical name

1-[3,4-Диэтоксифенил)мет илен]-6,7-диэтокси-1,2,3,4-��етрагидроизохинолин (as hydrochloride)

Gross

C24-H31-N-O4

Characteristics

Crystalline powder of light yellow color, odourless. Rat in the water and alcohol.

Of drugs

Drugs, the skin, miotroponoe, sossoudorasshiratee, gipotenzivne. Impact flow active ionized calcium in gladkomyshechne cells through inhibition fosfodiesterzy and intracellular accumulation Zamf. Quickly and completely absorbed in the digestive tract. The ingestion hazards close to 100% and the period poluabsorbtion-12 min. Evenly distributed over the fabric, enters gladkomyshechne cells. Excreted Pockami.vrajenno and expands the long-term smooth muscles of internal organs and vessels, reduces AD more minutes of the heart. Virtually no effect on the autonomic nervous system and enters the central nervous system.

Indications

Causes smooth muscles of internal organs (cardio and pilorospazm), a chronic gastroduodenit, saying disease stomach and duodenal ulcers, jelchnokamennaya disease (renal kolica), a chronic holetsistit, постхолецистэктомиче ский syndrome, gipermotornaya diskinesia biliary tract and spastical diskinesia bowel infection kolica due to the delayed gases after the operation, Colitis, proktit, tenezma, flatulence, filter disease (renal kolica) pielit, suffering cerebrovascular, coronary and peripheral arteries to calm reductions uterus and withdrawing acute cervical at birth causes smooth muscles at the time of the tool interventions.

Restrictions on the use of

Adenoma prostate expressed arteriosclerosis coronary arteries.

Contraindications

Hypersensitivity, glaucoma.

Side-Effects

The sense of heat, dizziness, adults, gipotenzia, rapid heartbeat, sweating (often with Injecting a), allergic dermatitis.

Patient interaction

Do (especially in the on / in the introduction) effect spazmolitikov others (including m-holinoblokatorov), hypotension caused tricyclic antidepressants, hinidine, novokainamidom. Reliability of the more acute phenobarbital. Decreases spazmogennouu activity morphine противопаркинсоничес кие properties of levodopa.

Overdosing

AV blockade, cardiac arrest, respiratory paralysis centre.

Dosing and Administration

Inside on 0,04-0,08 g 2-3 times a day. V / m, n / a, 2-4 ml 1-3 times a day, for the purpose of withdrawing cramps in / in slow 2-4 Jr. For children up to 6 years in the 0.01-0.02 g 1-2 times per day, children 6-12 years, 0.02 g 1-2 times a day.

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