No-spalgin

Roman name

No-Spalgin

Pharmacokinetics

Paracetamol and codeine do not affect the farmakokinetiku each other. Their farmakokinetika not be changed also in the second Prieme.mejdou paracetamolom drotaverinom and there is no interaction on bonding with blood plasma proteins. In tests in vitro showed that the paracetamol (in the range of therapeutic doses) nespecificski oppressing metabolism drotaverina (under similar effect in vivo). Components of the drug increased the AUC and S_max drotaverina. Components of the drug increased the AUC paracetamol, which leads to a significant reduction of Cl. The C_max paracetamol are within the 5495-6752 ng / ml, AUC_ | 0-24 | - 21760,8-26524,7 ng · h / l, and Cl - 356-418 ml / min.

Clinical pharmacology

It may be used as a painkiller in patients receiving combined indirect care.

Indications

Severe pain low and moderate intensity different genesis.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity to any of the components of the drug, severe kidney or liver failure, severe hear 1a482 t failure, AV blockade II extent, respiratory distress, bronchial asthma, treatment MAO inhibitors (for a period of 14 days after cancellation), the deficit glukozo-6-fosfatdegidrogenaza, chronic alcohol and drug abuse, after the skull fractures increased intracranial pressure of the blood (thrombocytopenia, lakopenia, granulozitos), the simultaneous application with the other �арацетамолсодержащи��и drugs, pregnancy, breast-feeding, child up to 6 years.

Side-Effects

In implementing the recommended therapeutic doses side effects occur Redko.u with increased sensitivity could experience allergic reaction (rash, tides blood to a person). Seldom-reduction actions, headache, dizziness, nausea, heart palpitations, drowsiness, constipation, it is very rarely bronhospazm, swelling of the nasal mucous membrane, or allergic reactions, the blood (agranulozitos, B19). When taken high doses of (mainly in the case of long term use) - Increased risk of bleeding, toxic liver damage in very high doses, irreversible tissue necrosis of the liver, with the possibility of death. Early symptoms of these violations are the paleness of skin, vomiting, increased sweating, nausea.

Specific guidance

For quick cupping pain is not recommended to take medication at the time of delivery. Do not exceed the recommended dose. The simultaneous use of other medicines containing paracetamol, it is not recommended. The reception drug alcohol is prohibited. When kidney or liver failure dosage must be Individuhalno.pri of preparation over three days, and / or the admission of the high doses needed to be monitored picture peripheral blood and functional status of the liver. Clinical and laboratory symptoms gepatotoksicski effect being felt within 48 to 72 hours after taking the drug on a large Dozah.ucitawaya what No-spalgin may, in some cases, cause drowsiness, and thus affect the ability to manage the transport and to work on the machines. The restriction or prohibition shall be installed individually.

Patient interaction

Because of drotaverina hydrochloride : at the same time with the application of levodopa, the most recent declines, the likely to worsen tremor and Rigidnosti.iz-za paracetamol content : in a joint application with drugs causing induction of liver enzymes (salicilamid, barbiturates, противоэпилептически е means Tricyclic antidepressants, alcohol, rifampicin), adds to the toxic metabolites of paracetamol; hloramfenikolom with increases last T_1/2 and increases its toxicity; simultaneous application with doksorubitsinom increases the risk of development of the liver; reduces the effectiveness urikozuriceskih products; metoclopramide and domperidon increase removals paracetamol and kolestiramin it reduces; in the long-term use drugs increases the risk of bleeding by the presence of Parazetmola.iz-za codeine : aggravating pills, painkillers and sedatives.

Precautions

In the case of long-administered to control the number of cells, platelets, as well as creatinine and the level of liver enzymes in the blood.

Storage conditions

At temperatures below 30 ° C

Shelf life

3 years

The registration

015036/01-2003

The drug forms

Svetlo-jeltae tablets with the exceptions of a better and more dark-coloured long, with a dividing mark on both sides.

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