Acetazolamide

Chemical name

N-[5-(Аминосульфонил)-1,3, 4-тиадиазол-2-ил]ацетам ид

Gross

C4-H6-N4-O3-S2

Characteristics

The white crystalline powder, insoluble in water and alcohol seems to be dissipating in scheloch.

Of drugs

The drugs-dioreticescoe. Ingibiruet carboangidrazou in renal proximal bone, reduces reabsorbqiyu ions Na, K, water (diurez increases), a metabolic acidosis and reduction BCC. Oppression carboangidraza resnitchatogo body reduces secreta watery moisture and decrease vnutriglaznogo pressure. Reducing carboangidraza activity in the brain is противоэпилептическу ю activity. Well drawn from the blood, C_max blood-in 2 hours The duration of up to 12 hours

Indications

Glaucoma, small seizures of epilepsy in children, rare absansa, oedema in the face of cardiopulmonary diseases (heart lung), the acute mountain sickness (prevention and treatment).

Restrictions on the use of

Pechenerngo oedema and renal genesis.

Contraindications

Гиперчувствительност ь (incl. to sulfanil- etc. sulfonamidam), the propensity to azidozu, Addison disease, acute liver disease and kidney problems, diabetes, uremia, pregnancy.

Side-Effects

Loss of appetite, nausea, vomiting, diarrhoea, parestesia, noise in the ears, the touch, drowsiness, and allergic reactions.

Patient interaction

Mochegonny effect increasing theofillinom declines kislotoobrazutmi dioretikami.

Dosing and Administration

Inside, and glaucome on 0,125-0,25 g 1-3 times a day every other day for 5 days, then break two days. In epilepsy - 0.25 g once a day, 3 days, the next day break. As dioretika on 0,125-0,25 g / day over a period of two to four days, then a few days break.

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