Etacrynic acid

Chemical name

[2,3-Дихлор-4-(2-метилен-1- оксобутил)фенокси]укс усная acid (and in the form of sodium salt)

Gross

C13-H12-Cl2-O4

Of drugs

The drugs-dioreticescoe. Applied throughout the bottom of the loop nefrona : oppressing reabsorbqiyu water and ions in the segment of colon and proximal kanalze. Increases excretion in the urine of sodium ions, chlorine, potassium, magnesium and calcium. Provides moderate antihypertensive activity. Enabling diureza begins in 60 minutes, reaching a maximum two hours and lasts 6-9 hours Dioreticeski effect is more pronounced on admission daily, and, with an 1-2 Dna.posle reception inside quickly and fully absorbed in a thin leg. Linking plasma protein-more than 90%. It permeates through the GEB. Metabolised in the liver. T_1/2 is 1-4 hours Excreted, for the most part, memory (60-80%) in the unmodified form (20-30%) and in the form of kongugatov; 20-30% return through the intestine.

Indications

Otechny syndrome different genesis (chronic heart failure, portal cirrhosis, nefrozy, hypertension, healthy lungs and the brain.

Contraindications

Hypersensitivity, anuria expressed violations vodno-elektrolitnogo acids and balance, hepatic coma, severe diabetes and gout, pregnancy, breast-feeding (at the time of treatment is halted), a young child (up to 2 years).

Side-Effects

Anorexia, nausea, vomiting, pain in the abdomen, diarrhoea, acute pancreatitis; Ortostatical hypotension, tachycardia, arrhythmia, ototoksicskie violations, dizziness, headache, muscle weakness, dehydration, metabolic acidosis, gipokaliemia, gipohloremia, giponatriemia, gipomagniemia, gipocalziemia.

Patient interaction

Kalisberegate dioretiki heighten effect and reduces gipokaliemia and alkaloz. Deepens hypotension caused beta-adrenoblokatorami, apressinom, verapamilom, nifedipinom, captoprilom, Clonidine, metildofa, octadine, prazosinem, rezerpinom, ganglioblokatorami (ortostaticeski possible collapse). Combined with indirect antikoagulyantami glukokortikoidami and more significantly improves salurez and gipokaliemia. Increases big nefrotoksicnosti and other drugs and the degree of dehydration in the face of laxatives drugs.

Overdosing

Symptoms : expressed violations vodno-elektrolitnogo exchange (gipokaliemia, gipohloremia, gipovolemia), the metabolic alkaloz Arterial gipotenzia, Aritmii.lechenie : stomach scene, the introduction of products correcting kislotno-schelocna balance (drugs potassium); If necessary recovery actions to restore the respiratory and cardiovascular system.

Precautions

In zirrozah liver application requires careful medical supervision. Treatment should be held against the backdrop of a diet rich in potassium, and, if necessary, to appoint him drugs.

Dosing and Administration

Inside, on the morning after delivery, starting with 0.05 g / day, adding to the daily dose of 0.1-0.2 to the city

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