Hydrochlorothiazide

Chemical name

6-Хлор-3,4-дигидро-2Н-1,2,4- бензотиадиазин-7-суль��онамид-1,1-диоксид

Gross

C7-H8-Cl-N3-O4-S2

Characteristics

White or yellow white crystalline powder. It is soluble in water, alcohol, it is easy in alkaline solutions.

Of drugs

The drugs-dioreticescoe, gipotenzivne. Impact reabsorbqiyu ions of sodium and chlorine (to a lesser extent, potassium and bicarbonate) in the proximal bone kidney removal magnesium, calcium, uric acid. Increases concentratinuu the kidneys. Oppressing susceptibility vascular wall of the excitatory influences mediators for the decrease in BCC, as well as the fall of the concentration of sodium ions in zitoplazme miotitov receptacles. It absorbed in the digestive tract. In the blood of 60% is associated with malnutrition. Penetrates through gematoplatzentarnyi barrier, and in breast milk. Report the news. Dioreticescoe to develop 30 to 60 minutes, reaching a maximum at 12 hrs

Indications

Arterial hypertension, female heart failure, glaucoma, nesharnyi diabetes, cirrhosis gantries with hypertension and otern-astiticeski syndrome, jade, principally; Rarely Toxaemia.

Restrictions on the use of

Severe cerebral or coronary arteriosclerosis expressed by the human liver, kidneys, pregnancy.

Contraindications

Hypersensitivity, diabetes, gout, breast-feeding (a non-breast-feeding).

Side-Effects

Gipokaliemia, gipohloremicski alkaloz, nausea, vomiting, loss of appetite, diarrhea, constipation, appetite, dizziness, headache, weakness, parestesia, ortostatical gipotenzia, tachycardia, holetaz, pancreatitis, gemoliz, gipoplastical anaemia, agranulozitos, allergic reactions.

Patient interaction

Do toxicity cardiac glycosides, nedepoliarizuth miorelaksantov. Decreases effect of oral contraceptives. Reduces down lithium salts.

Overdosing

Brown mouth, weakness, drowsiness, tachycardia, hypotension, oliguria.

Precautions

In the long-term therapy requires monitoring of electrolytes in the plasma.

Dosing and Administration

Inside, and hypertension - 100 mg once a day, with heart failure and cirrhosis, and 200 mg / sut. For children daily dose of 2 mg / kg with a maximum dose up to the age of 6 months, 3.5 mg / kg / day, up to two years 12,5-37,5 mg / day, 3-12 years, 100 mg / sut.

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