Indapamide

Chemical name

3-(Аминосульфонил)-4-хл��р-N-(2,3-дигидро-2-метил-1 Н-индол-1-ил)бензамид (and in the form of hemihydrate)

Gross

C16-H16-Cl-N3-O3-S

Characteristics

White or jeltovato-bely crystalline powder, soluble in aqueous solutions of strong alkalis.

Of drugs

The drugs-dioreticescoe, sossoudorasshiratee, gipotenzivne. Ingibiruet retroactive removal of sodium ions in korticalnom segment hinges nefrona increases in the urine sodium ions, chlorine, calcium and magnesium. Impact sensitivity of the vascular wall to norarenalino and angiotenzino II; Stimulates synthesis PGE_2; Oppressing current calcium ions in gladkomyshechne vascular cell stacks, and thus reduces OPPS. Impact products free and stable oxygen radicals. Quickly and completely absorbed by ingestion. C_max up in 2 hours The plasma to 71-79% is associated with malnutrition, can sorbirovtsa and cell. Passes through gistogematicalkie barriers (including placental), enters the breast milk. T_1/2 about 2:00 pm 70% excreted kidneys and 23% from faeces. Indapamid excreted unchanged to and in the form of metabolites (7%). And dozozawisimam effect. The dose of 2.5 mg is the maximum gipotenzivne effect with a slight increase diureza.

Indications

Arterial hypertension, chronic heart failure.

Contraindications

Hypersensitivity, violations of cerebral circulation, severe liver failure, diabetes under decompensation, gout, pregnancy and breast-feeding (at the time of treatment, it is necessary to give up breast-feeding).

Side-Effects

Weak, ortostatical hypotension, gipokaliemia, giperuriquemia, nausea, pain in epigastria, diarrhoea, convulsions, allergic reactions.

Patient interaction

Do the gipotenziveh drugs increases the risk gipokaliemii against kaliwavodath dioretikov.

Overdosing

Symptoms : weakness, the vodno-elektrolitnogo balance, respiratory depression, Gipotonia.lechenie : Correction vodno-elektrolitnogo balance may wash stomach.

Precautions

In appointing patients with diseases of liver and kidney, it was necessary to monitor the level of potassium in the blood. Patients who are gieperriquemiei the best approach is to determine the content of uric acid in the blood. It should not be combined with drugs lithium winkaminom, kaliwavodaschimi dioretikami.

Dosing and Administration

Inside, in the 2.5 mg or 1.5 mg (tabl.retard) per day (preferably morning). The maximum daily dose of 10 mg.

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