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Indapres

See also Indapamide

Roman name

Indapres

Characteristics

Derived benzamidov, tiazidopodobnyy diuretic. Has mild prolonged effect.

Pharmacokinetics

Once inside indapamid rapidly absorbed from the digestive tract. T_max in plasma is 1-2 hour. Linking blood plasma is 70-79%. The readmission pharmacokinetic parameters can be changed, indicating a minimal risk cumulation. Indapamid out with breast milk. High lipophilic indapamida provides T_1/2 long (up to 18 hours). Report from the body very slowly, mostly kidneys (about 60%), in most cases, in the form of metabolites, 5% in an unmodified form.

Farmakodinamika

Decreases suffering left heart chamber. There is a negative impact on lipid profile (total cholesterol, cholesterol engineers and triglycerides), and does not violate the metabolism of glucose, even in patients with diabetes.

Clinical pharmacology

In arterial hypertension in the dose of 2.5 mg per day, is valid for 24 hours When increasing dosage gipotenzivny effect is not increased, but increased dioreticescoe effect.

Indications

Primary arterial hypertension.

Pregnancy and lactation

Contraindicated.

Contraindications

Hypersensitivity, incl. derivatives sulfonamidov; acute violation think krovtreatmenia expressed by the human liver; terms of the kidneys, anuria; diabetes under decompensation; gout, pregnancy and breastfeeding.

Patient interaction

Together with the use of cardiac glycosides and korticosteroidami increased risk of gipokaliemii. If you are a drug lithium increases the risk of lithium intoxication in the face of reduced renal clearance of lithium. Do the gipotenziveh PP.

Precautions

In appointing patients with diseases of liver and kidney, it was necessary to monitor the level of potassium in the blood. Patients who are gieperriquemiei the best approach is to determine the content of uric acid in Krovi.ne recommended drug in children because of a lack of evidence to prove the effectiveness and safety of use in this age Groupe.ne should be applied in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Storage conditions

List B. In the dark and moisture place with a temperature of 15-25 ° C

Shelf life

3 years

The registration

(OL)

The drug forms

Tablets 2.5 mg Film-coated, white separable, round, oboudostoronne 4.2.2. Surface tablets smooth, homogeneous. On one side there is a pill groove that makes it easy to divide Tabletki.tabletki 1.25 mg Film-coated, orange, round, oboudostoronne 4.2.2. Surface tablets smooth, homogeneous.

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