Mannitol

Chemical name

D-mannit

Gross

C6-H14-O6

Characteristics

Liofilizirovannaya mass light amber. Rastvorima in water (preferably in the hot).

Of drugs

The drugs-protivooterne, dioreticescoe. KISR increases pressure in the bone and prevents reabsorbtion water. Filtered news without further kanalzeva reabsorbtion, resulting in the retention of water in the bone and increased urine. At the same time, increases natrillurez without significantly increasing kaliyureza. The strength of the above, the higher dose. Not good if there is a violation of filtering kidney functions, as well as in azotemii in patients with cirrhosis of the liver, and aszitom. It is the BCC (due to the increase in osmotic pressure sossoudistom line).

Indications

Swelling brain, the vnutricerepnogo pressure or renal insufficiency pochern-pechenocna, apparently of acute glaucoma attack transactions with ekstrakorporalnam blood, acute renal (with filtering saved the kidney) and liver failure, posttransfuzie complications caused by the incompatible blood, acute poisoning barbituratami and other substances (diurez +68).

Contraindications

Hypersensitivity, severe kidney failure, a breach of filter functions kidney female heart failure, haemorrhagic stroke, arachnoidal bleeding (except bleeding in the skull trepanation) giponatriemia, gipohloremia, gipokaliemia.

Side-Effects

Dehydration, neuralgia, hallucinations, violations elektrolitnogo balance.

Specific guidance

10% solution can be prepared at room temperature, 15% and 20% solutions, with the warming water bath to 37 ^ C. The 20% solution mannita, especially when it cooled, can be formed crystals to dissolve necessary to heat a bottle in hot water or avtoklave periodically ustrahivaya. The application must be cooled to a temperature of the body or lower.

Precautions

The exercise if levojeludockova insufficient for the risk of lung inflammation; , In order to avoid this in these cases to be combined with mannit quick petlevami saluretikami. Therapy should be supervised vodno-elektrolitnogo balance and the central hemodynamics.

Dosing and Administration

B / in (struino or drip), in the form of 20% solution in the dose of 0.5-1.5 g / kg; Daily dose should not exceed 180 and Liofilizirovannuu mass initiation ex tempore water for injection, or 5% glucose solution. In transactions with the artificial blood immediately prior to the white machine in the 20-40 entering the city

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