Trometamol

Chemical name

2-Амино-2-(гидроксимети л)-1,3-пропандиол

Gross

C4-H11-N-O3

Characteristics

The white crystalline powder. Easily soluble in water. An aqueous solution is alkaline reaction.

Of drugs

Drugs, the normalizing KHS, dioreticescoe. The on / in a lower concentration of hydrogen ions and increases the alkaline pool of blood, thereby eliminating the azidemiu, permeates through the membrane into cells and helps eliminate intracellular azidoza fully displayed news, unedited, and stimulates diurez. The ingestion of a salt slabitelnoe.

Indications

Diseases associated metabolic azidozom, incl. diabetic ketoacidosis, poisoning salicilatami, barbituratami, metilovam alcohol, the appointment allopourinola (prevention azidoza).

Restrictions on the use of

Moderate kidney and / or liver failure, respiratory distress.

Contraindications

Hypersensitivity, severe kidney failure.

Side-Effects

CHD deficiency, gipotenzia, diarrhoea disorders, hypoglycaemia.

Patient interaction

Do effects of narcotic analgesics, aminoglikozidov, macrolides (erythromycin, oleandomitina), chloramphenicol, tricyclic antidepressants weakens indirect anticoagulants (coumarin derivatives), barbiturates, salicilatov.

Overdosing

It has increased side effects (periodic breath gipotenzia, nausea, vomiting, hypoglycaemia). Treatment of symptomatic.

Precautions

Required monitoring of glucose and electrolytes blood KHS.

Dosing and Administration

In / in the Quick 120 drops / min (most of the speed is not recommended, in order to avoid side effects), dose calculated from the formula : K = Bhe, where K is the number of 3.66% solution trometamola (ml), B-basis deficit (mmol / l), E is the mass of the patient (kg). The maximum dose of 1.5 g / kg / sut. Re-introduction to the 48-72 hours

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