Xipamide

Chemical name

5-(Аминосулфонил)-4-хло��-N-(2,6-диметилфенил)-2-г��дроксибензамид

Gross

C15-H15-Cl-N2-O4-S

Of drugs

The drugs-dioreticescoe. Ingibiruet reabsorbqiyu sodium, chlorine, carbonates, calcium, magnesium and water. Quickly and sufficiently absorbed after administration inwards. C_max through 1hr The blood virtually all (99%) relates to the protein. Biotransformiroetsa in liver education glikuronida. Excreted mainly kidneys, a small part (as glikuronida) is the faeces. T_1/2 in patients without disabilities kidneys and the liver is 160161 and changed slightly, even if oppressed urinary excretion. The ability to raise ksipamida diurez does not depend on the baseline speed clubockova filtering, and the effect is even in the terminal stages of kidney failure; Dioreticeski effect made through one hour after taking into and reaches maximum between 3 and 6 hours; Excretion of sodium and chlorine remains elevated for 12 to 24 hours The hypotension, which at the beginning of treatment associated with a decrease in the volume of extracellular fluid; In the long-term use of vnekletocny returned to the original level, but gipotenzia, that explain the decrease in the concentration of sodium in the vessel wall and the decline of its response to noradrenalin and angiotenzin II.

Indications

Arterial hypertension, otechny syndrome and diseases of heart, liver and kidney, cardiac and renal failure, liver.

Restrictions on the use of

Violations of the kidney or liver.

Contraindications

Hypersensitivity, heavy human liver (hepatic coma), gipokaliemia, giponatriemia, giperuriquemia, gout (incl. history).

Side-Effects

Gipokaliemia, giponatriemia, gipomagniemia, gipohloremicski alkaloz, headache, dizziness, dry mouth, ortostatical gipotenzia, drowsiness, muscle cramps, anxiety, causing diarrhoea disorders giperuriquemia, increased blood coagulability intersticialny severe cases, jaundice, vasculit, aplastic anaemia, agranulozitos, lakopenia, thrombocytopenia, photosensitization, allergic reactions.

Specific guidance

Against the backdrop of the reception (especially in combination with alcohol) down the reaction rate.

Patient interaction

Gipotenzivny and dioreticeski effects reduce NPVS. While others dioretikov, antigipertenziveh drugs, nitrates, ACE inhibitors, barbiturates, fenotiazinov, tricyclic antidepressants, ethanol and etanolsoderjath drugs increases the likelihood of excessive loss AD. Decreases of gipoglikemisiruth and protivopodagricakih of adrenalin and norarenalina increased cardio and neurotoxicity lithium products, in combination with cardiac glycosides, saluretikami, korticosteroidami, slabitionami, amfoteritinom B carbenaksolonom, penicillin, salicilatami increases the risk of gipokaliemii and / or gipomagniemii. Together with the application nedepoliarizutmi miorelaxanthami can go neiromyshecnaya blockade.

Overdosing

Many of persistirutego diureza, gipokaliemiei, aritmiami, giponatriemiei, arterial gipotenziei.

Precautions

The treatment should keep the blood potassium, sodium, urea, creatinine, uric acid, glucose, lipids, as well as AD curves and EKG, patients should receive adequate fluid and food rich in potassium.

Dosing and Administration

Inside, in the morning, after breakfast, a pancake of water. The average daily intake of 10 to 30-mg (if necessary 40 mg) in the 1-2 receiving supporting-10 mg / sut.

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