Alprostadil

Chemical name

(11альфа,13E,15S)-11,15-Дигид��окси-9-оксопрост-13-ен-1 -овая acid (and in the form of the �льфа-циклодекстрином �latratom)

Gross

C20-H34-O5

Characteristics

White or no white crystalline powder with a melting point of 110 to 116 ^ C.

Of drugs

The drugs-sossoudorasshiratee, antiagregatine, improves microcirculation in the penis. It improves microcirculation in the penis. The decrease muscles gladkomyshechnykh bodies pressure increases and increases peripheral blood, improves hampered agregatia and activates juvenile Trombozitov.posle intrauretralnogo of about 80% quickly-within 10 minutes - absorbed by the mucous membrane in the urethra sponge body. Part imposed doses distributed in the body Yupopov@dol.ru (through kollateriona receptacles), the balance in the venous perineum; Got to the central venous blood alprostadil almost completely withdrawn from circulation system Light; T_1/2-odd minutes. In the introduction, and mainly in the lungs (60-90%) is metabolized in the formation of various derivative Pge_1.effekta develop within 5-10 minutes after the introduction and continuing 30-60 min. The kavernozhnykh arteries and receptacles trabecula smooth muscles pescheristah phone leads to a rapid flow of blood and dilatation lakunarnah spaces pescheristah Bodies; Venous outflow through the receptacles are located under the eyelids liner difficult and develops penis (the so-call 70b3 ed "korporalny venookkluzionny mechanism).

Indications

Un neirogenna dysfunction, vascular, psihogenna or mixed etiology; The pharmaceutical samples at the diagnostic tests the violations exist.

Contraindications

Hypersensitivity, anomalies of the penis (strictora urethra expressed deformity, balanit, Baby); Sickle cell anaemia (also for suspicion), thrombocytopenia, policitemia, multiple mieloma, venous thrombosis (including predisposition), high viscosity of blood.

Side-Effects

The pain in the penis, prolonged or painful erection and priapizm, fibrosis and swelling of the penis, skin on the penis, balanit, bleeding from the urethra, a burning sensation in the penis, swelling, Fungus infection, irritation, fimoz, pocesuha, erythema, the ejaculate, testicular swelling, tied voltage, frequency of urination, urinary; Fluctuations AD supraventrikuliarnaya arrythmia, peripheral vascular violations; dizziness, headache, gipestesia; weakness in the buttocks, localized pain (in the buttocks, legs, sexual organs abdomen), the pain in the pelvis, lumbar, grippopodobnyy syndrome, bruises gemorragii inflammation, swelling, itching at the injection.

Specific guidance

The confused with the other solutions products.

Patient interaction

Combined increase (each), the risk of bleeding.

Overdosing

Symptoms : gipotenzia, pain in the penis, prolonged erection (6900 and more), irreversible deterioration flaccid Funktion.lechenie : symptomatic.

Precautions

Selection dose should be under the supervision of a physician, under the control of the cardiovascular system and the duration of erection. The patient should be warned that in the healing process, it must inform the doctor of all cases of erectile longer than 6 hours During treatment it is necessary to use adequate contraception method jenshchina-partnerom childbearing age. Perhaps feeling a stinging and itching in the vagina jenshchin-partner.

Dosing and Administration

Intrauretralno in applikatora imposed uretru after urination. Dose picked individually Recommended home-Validity vehicle, one; If necessary dose gradually raise (or lower) to achieve erection sufficient for sexual intercourse. Maximum frequency of a maximum of two systems within 24 hours

Directory → Organotropona funds → The governing bodies of the urinary and reproduction → Regulators potency → Alprostadil