Finasteride

Chemical name

N-трет-Бутил-3-оксо-4-аз��-5альфа-андрост-1-ен-17б ета-карбоксамид

Gross

C23-H36-N2-O2

Characteristics

White crystalline powder, insoluble in water.

Of drugs

The drugs-antiandrogennoe. Forms slowly dissocerute (dissociation period of 30 days) complexes with cellular 5-alfa-reduktaza, ingibiruet make testosterone during the active 5-alfa-digidrotestosteron, with a resulting increase in tissue prostate cancer or its development Giperplazii.bystro sound, and almost completely (bioavailability 80%) absorbed in the digestive tract. C_max achieved in 1-2 hours The plasma 90% is associated with malnutrition. Place in the form of metabolites kidneys (39%) and through the intestine (57%), T_1/2 C.dlitionay 6-8 (3-7 months) admission to the dose of 5 mg / day reduced the concentration of 5-альфа-дигидротестос��ерона in the serum of 70%. Decreases of cancer, normalizes amended urodinamiku : increases the maximum speed of current urine and the road urinary tract infections. The 50% of patients with clinical symptoms disappear within 12 months.

Indications

Safe giperplazia prostate cancer, including of the violation of urodynamics.

Contraindications

Hypersensitivity, obstructive uropatia cancer prostate cancer, pregnancy, child.

Side-Effects

Impotence, ginekomastia, lowering pill and the volume, the increase in pain and thoracic surgery, the blood levels and LG opened.

Patient interaction

Increases effect antikoagulih and antidiabetics funds.

Precautions

A high volume of residual urine and reduced its current, it should be borne in mind the possibility of obstructive uropathy. Prior to the start of treatment should be deleted cancer prostate cancer and prostate infection. Pregnant women of childbearing age to avoid contact with crashed tablets finasterida because possible entry into the body and the development of the external genital organs in the fruit.

Dosing and Administration

Inside, regardless of the meal, 1 tab. (5 mg) per day for 6-7 months. The first assessment of the effectiveness of the six months.

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