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Kamiren

See also Doxazosin

Roman name

Kamiren

The composition and the form of

1 tablet contains doksazosine 1, 2 or 4 mg; in a contour acheikova packing 10 pcs. , in a cardboard bundle two or three packages.

Of drugs

Gipotenzivne, sossoudorasshiratee, gipolipidemicescoe, skin. Yes blocks postsinapticalkie альфа_1-адренорецепто��ы. Impact round, the level of total cholesterol, engineers and triglycerides and increases LPVP content in the serum. Warn of atherosclerosis and ischemic heart disease, ingibiruet agregatia platelets. Decreases estate left chamber (with extended care). Prevents reducing smooth muscle top of the urethra and muscles prostate, helps to alleviate the bed and remove dizuriceskih symptoms Accompanying good giperplaziu prostate gland.

Pharmacokinetics

Well drawn from the blood, C_max achieved through 1.5-3 hours Almost entirely associated with plasma proteins, metabolised in the liver. T_1/2 - 16-22 h. Displays, including in the form of metabolites, mainly faeces less than 10% from urine.

Clinical pharmacology

Gipotenzivne the most was within 2-6 h after administration of the drug and continued for 24 hours The maximum effect was achieved after weeks of the regular admission. Effects of the normal AD slightly. It may be used in patients with renal failure, COPD chronic respiratory diseases, peripheral angiopatiei, podagra and diabetes type 2.

Indications

Arterial hypertension mild to moderate severity (monotherapy or in combination with other drugs antigipertenzivei) Good giperplazia prostate cancer (symptomatic treatment).

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, incl. other derivative hinazolina (prazosin, terzozin), or to other components of an occlusion or blood oesophagus, stomach down any extent, child.

Side-Effects

From the circulatory system and blood (blood, gemostaz) : Arterial gipotenzia (especially at the beginning of treatment and when the dosage migrate from the lying or sitting position standing), it is very rarely increased stroke, myocardial infarction, stroke zerebrovskulyarnyi violation heart rhythm (but not found The cause is the use of doksazosine); Trombozitopenia.so the respiratory system : nose zalojennosti or separation from the nose, flu symptoms, bronchitis, Odyshka.so part of the intestine : very rarely nausea, holetaz, hepatitis, a violation of the Pecheni.so the musculoskeletal system : muscle Slabostj.so the nervous system and sensory organs : dizziness, headache, feeling of tiredness, Sonlivosti.so the skin : very rarely skin rashes, Purpura.prochie : gematuria NOSE bleeding, swelling ankles and thighs.

Patient interaction

Effect increase beta-adrenoblokatora, dioretiki, calcium blockers channels enzyme inhibitors, nitrates, anaesthetics, Tricyclic antidepressants and alcohol.

Overdosing

Symptoms : arterial gipotenzia, dizziness, Obmorok.lechenie : stomach wash, the use of activated charcoal, laxatives funds norarenalina; Hepatology ineffective.

Precautions

To use caution in patients with liver impairment. To avoid Orthostatic hypotension treatment should start with a dose of 1 mg evening before bedtime. There is a need to be careful when moving from the lying or sitting position Stoja.pered the treatment safe hyperplasia prostate cancer patients need to be surveyed urologom. Caution must be exercised while receiving drugs that affect liver metabolism. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, regardless of the reception Pishchi.arterialnaya hypertension and sound giperplazia prostate cancer in patients with arterial hypertension : initial dose (evening at night), 1 mg / day, with a gradual increase to 2 4 and 8 mg once a day at intervals of 1-2 weeks. Normal daily intake - 2-8 mg, the maximum-16 Mg.dobrokacestvennaya giperplazia prostate cancer in patients with normal blood pressure : initial dose (evening before bedtime) -1 mg / day with a gradual increase to 2 4 and 8 mg once a day (range 1-2 weeks). The average daily intake from 2 to 4 mg, the maximum 8 mg.

Storage conditions

table. : List B. The temperature is not above 30 ° C

Shelf life

table. : 3 and

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