Prazosin

Chemical name

1-(4-Амино-6,7-диметокси-2 -хиназолинил)-4-(2-фуран илкарбонил)пиперазин (and as hydrochloride)

Gross

C19-H21-N5-O4

Characteristics

White or white with kremovatam white crystalline powder. Very poorly soluble in 95% ethanol, nerastvorim almost in the water.

Of drugs

The drugs-sossoudorasshiratee, gipotenzivne, antidizuricescoe. Yes blocks postsinapticalkie альфа_1-адренорецепто��ы. Rapidly absorbed in the intestine, speed technique does not depend on the meals. Bioavailability-85%. The blood linked to the supply by 97%. As a result, degradation in the liver produces metabolita 4, which accounted for up to 25% of pharmacological activity. T_1/2 2-4 h with kidney failure and the elderly, it increases. Excreted, for the most part, expressed Jelchew.okazavaet gipotenzivne effect without significantly increasing HR. Impact round, expands storage and the resistive pressure. The lower the pressure in the pulmonary veins and the right predserdii, moderately-lung vascular resistance. A first dose of a sharp drop AD (especially ortostaze against a backdrop of the admission dioretikov). Following the lifting and the subsequent appointment in a week that the effect of the first dose is not yet in sight. Decreases occurred need of oxygen increases the impact of the physical activity. Provides minimal impact on the delay of liquid in the body, does not lead to an increase in body mass index, does not alter the rate of filtration and kidney blood reduces renal resistance vessels. Peak gipotenzivnogo effect after a single dose through a 1-4 hour duration, until 10:00. It may develop as early (in 4-5 days), and late (by 12 months) tolerance, which calls for increasing doses. Prospects affects lipid spectrum : a decline in the level of total cholesterol, triglycerides, LPONP and engineers; does not alter the tolerance to carbohydrates or metabolism of uric acid.

Indications

Arterial hypertension, heart failure initial stages. Adenoma prostate gland.

Restrictions on the use of

Giponatriemia.

Contraindications

Гиперчувствительност ь (incl. to hinazolinam etc.), heart failure in the face of constroguogo pericardita, tampondy heart, defects with a slight reduction in the pressure of filling the left chamber, pregnancy, breast-feeding (must stop breastfeeding).

Side-Effects

The phenomenon of the first dose (severe hypotension in ortostaticescom situation collapses, headache, weakness, rapid heartbeat), sleep disorders, weakness, fatigue, depression, anxiety, nausea, dry mouth, diarrhea, frequent urination, swelling, lower limbs, rash.

Specific guidance

It regularly monitor AD and curves in the standing, and lying. Probability hypotonia higher among patients receiving dioretiki, simpatolitiki, beta-adrenoblokatora.

Patient interaction

Do gipotenzivny effect бета-адреноблокаторо�� and dioretikov.

Dosing and Administration

Inside. Initial dose-0.5-1 mg at night in a horizontal position, followed by 1 mg 2-3 times a day. The intervals of 5-7 days, the daily dose may be increased to 15 mg (reception 2-3), maximum daily dose of 20 mg, the maximum effect is four to six weeks.

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