Terazosin

Chemical name

1-(4-Амино-6,7-диметокси-2 -хиназолинил)-4-[(тетра��идро-2-фуранил)карбон��л] piperazine (as hydrochloride)

Gross

C19-H25-N5-O4

Characteristics

The white crystalline powder dissolves easily in water.

Of drugs

The drugs-sossoudorasshiratee, antidizuricescoe, gipolipidemicescoe. Selectively blocking альфа_1-адренорецепто��ы smooth muscles crevnykh pressure, prostate and uterine bladder. Increase large resistive pressure and reduces round (gipotenzia), the system activates ренин-ангиотензин-аль достерон. Relaxes smooth muscles neck bladder and sokratitiona elements of the prostate, reduces dizuriceskih events when its adenome. Normalizes lipid profile plasma (reduces the total cholesterol, triglycerides and LPONP reasonable, adds LPVP). When these features are exaggerated left Jeludocka.posle intake of fast and complete skin (bioavailability over 90%); because presistemnaya biotransformation negligible C_max achieved within 1 h. The plasma at 90-94% linked to the protein. The liver is metabolita 4. T_1/2-12 p.m. 40% excreted memory (up to 10% in an unmodified form), and 60% - intestinal (more than half in the form of sleep). When liver pathology reduced Cl, and the effects пролонгируются.Гипот��нзия begins in 15 minutes, a 1-2 hour is the maximum, until 24 p.m. The sound hyperplasia prostate cancer clinical improvement made through two weeks of admission, resistant and therapeutic effect for a period of 4-6 weeks.

Indications

Arterial hypertension, prostate adenoma cancer, heart failure at the primary stage giperlipidemia.

Contraindications

Hypersensitivity and hypotension, pregnancy, breast-feeding (at the end of treatment), children's age.

Side-Effects

Weakness, fatigue, drowsiness, confusion, headache, dizziness, parestesia, reduced libido, impaired vision, noise in the ears, "phenomenon of the first dose (fall AD until ortostaticski collapse, the first admission), hypotension, tachycardia, arrhythmia, peripheral edema, cough, bronchitis, xerostomia, pharyngitis, nausea, vomiting, artralgia, mialgia, reducing gematokrita and hemoglobin, lakopenia, gipoalbuminemia, gipoproteinemia, grippopodobnyy syndrome, allergic reactions.

Patient interaction

Do gipotenzivnuu activity mochegonnah, adrenoblokatorov, calcium antagonists, miotroponah the health oppressive system ренин-ангиотензин-аль достерон.Антациды adsorbents and reduce intake. Adrenomimetiki weaken efficiency.

Overdosing

Symptoms : tachycardia, hypotension, ortostaticeski Kollaps.lechenie : Relocation patient in a horizontal position, with a closed head end of the bed, in / in a liquid gipertenziveh drugs.

Precautions

To prevent collapse ortostaticski initial dose should not exceed 1 mg and assign it should be at night (in the trunk).

Dosing and Administration

Inside. At 1 mg once at night; Dose gradually increase to a range of 10 to 20 mg (not more than) 1 per day.

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