Hexoprenaline

Chemical name

4,4'-[1,6-Гександиилбис[и��ино(1-гидрокси-2,1-этан��иил)]]бис-1,2-бензолдио�� (and as dihydrochloride or sulfate)

Gross

C22-H32-N2-O6

Of drugs

The drugs-bronhodilatirtee, tokoliticescoe. Yes stimulates бета_2-адренорецептор�� smooth muscles bronchus, cervix, adenilatziklazu activates and increases the Zamf, thereby reducing the concentration of intracellular Calzia.rasshiraet bronchi by relaxing smooth muscles. It prevents the release of biologically active substances gistamina, lakotrien D4, etc. from the fat cells. Tokoliticeski effect is relaxation double uterus, the lower the frequency and intensity of reductions. Stupid and suffered from auxitotinom tribal clashes. Terminates premature contractions (in most cases), which extends the pregnancy to normal due date. During birth regulate excessively high or irregular contractions. In the middle dosage has no significant impact on the variation. Does glikogenoliz.

Indications

In obstetric practice : treatment of acute conditions for braking ancestral turf in childbirth (with discoordinirovanna delivery of acute fetal intrauterine asphyxia); For the immobilization of the cervical operational or obstetric intervention (Caesarean section manual adjustment of the fruit, cutting hair, abnormal genetic activity); For the suppression of premature labor treatment stage. Prolonged treatment for the prevention of premature births or enhanced frequent battles with shorter or disclosure of the cervix before, during and after the surgical interventions to stem Matki.v Pulmonology : for cupping bronchoobstructive syndrome with acute bronchial asthma and chronic obstructive disease, the reaction bronhospasticskie different genesis, prevention of attacks of asthma.

Contraindications

Hypersensitivity, incl. to sulfitam, premature detachment of the placenta, breeding haemorrhage, infection endometrium, cardiovascular disease, accompanied by tahiaritmiami, myocarditis, heart disease (mitrale, aortalny stenoses), cardiomyopathy, incl. idiopathic gipertroficski subaortalny stenoses, ischemic heart disease, arterial hypertension, severe liver disease and kidney Ray, zakratougolnaya glaucoma, I trimester of pregnancy.

Side-Effects

Headache, dizziness, anxiety, muscle tremor, sweating, tachycardia, ventricular arrythmia, pain in the heart, a result of the sharp decline in AD weakening peristalsis and atony bowel giperglikemia, increasing transaminaz, gipokaliemia, reducing diureza, oedema; Newborn possible hypoglycaemia and disorders, acute bronhospazm, anaphylactic shock.

Patient interaction

Effect reduce selective beta-adrenoblokatora increase metilxantina (theofillin). Simpatomimetiki means to narcosis (ftorotan) increased side effects of the cardiovascular system. Decreases activity saharosnijath oral drugs.

Overdosing

Symptoms : anxiety, anxiety, distal melcorazmashisty tremor, sweating expressed tachycardia, the disruptions to the heart, headaches, sweating, cardialgii Arterial gipotenzia, Odyshka.lechenie : appointment selective бета-адреноблокаторо�� (propranolol).

Precautions

The caution (with the regular monitoring of glucose in the blood serum), applied with a concomitant diabetes mellitus (giperglikemia possible). Before treatment shows intake of potassium, sodium restriction of salt and fluid. In appointing during pregnancy to control gemodinamicakih performance in the mother and fetus, the fetoplatzentarnogo complex. Not recommended geksoprenalin combine with antidepressants, drugs calcium and vitamin D_3, минералокортикоидами .

Dosing and Administration

B / struino in (slow), or drip, inwards Ingaltin.ostrae of obstetric practice, and 10 µ g in 10 ml of physiological solution or glucose give / in the slow (5-10 minutes), in further testimony to continue in / drip in a Quick 0.3 µ g / Min.dla suppression of premature labor-10 micrograms become / in struino slowly then the same dose of / drip in 500 ml of physiological solution, or 5% solution Glukozy.dl long-term care insurance-0.075 µ g / min in / in the drip, in the absence of a resumption of the delivery within two days continues ingesting 0.5 mg every 15 hours, and then every 4-6 C.pri treatment bronchoobstructive syndrome inwards within 30 minutes before eating, adults and 1 table. three times a day, if necessary - 2 table. three times a day, or at one table. every 4 hours Children : 6 months to 1 / 4 table. 1-2 times a day, 12 months-1 / 4 table. 1-3 times a day, 1-3 year-1/4-G table. 1-3 times a day, 3-6 years - 1 / 2 table. 1-3 times daily, 6-10 years - 1 table. 1-3 times a Sutki.ingaltin-dose injection out during prolonged intensive deep breaths, followed by a delay in the air with 6-8, adults and children older than 3 years, 1-2 dose for acute edema attack suffocation breathing again no earlier than 30 Min.pri amok prolonged suffocation and inefficiency inhalation and tablets of possibly / jet in a slow drip or (200 ml of physiological solution, or 5% glucose solution) Introduction 2 adults ml, the maximum 4 ml, astmaticescom with status-2 ml 3-4 times a day. Children : 3-6 months, and 1 µ g, 6-12 months-2 µ g, 1-3 years, 2-3 µ g, 3-10 years, 3-4. 2.4.3.

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