Salbutamol

Chemical name

альфа1-[[(1,1-Диметилэти��)амино]метил]-4-гидрок��и-1,3-бензолдиметанол (in the form of sulfate)

Gross

C5-H5-N5-S

Of drugs

The drugs-bronhodilatirtee, tokoliticescoe. Vsokoseleguo beta_2-adrainoretseptora stimulates, activates intracellular adenilatziklazu. Bronholiticeski effect from rasslableniem smooth muscles bronchi. Not destroyed lung катехол-О-метилтрансф еразой and the long-term. Relaksiruet uterus hampered Oxytocics Oxytocics activity, warns premature Roda.pri inhalation 10-20% is small bronchi and gradually absorbed, part of the dose swallowed absorbed from the digestive tract. Using tablets prolonged action well absorbed. C_max is 30 ng / J The circulation in the blood at the department level is 3-9 h, and then the concentration is gradually decreasing. Linking plasma protein-10%. Treated biotransformation in the liver. T_1/2 3.8 hours Report irrespective of the mode of the urine and jelchew, mostly unchanged to (90%) or in the form of глюкуронида.Максимал��ная speed action (withdrawal bronchospasm) is achieved with the inhalation introduction. Bronhodilatation is already th minute, rising to the 20th minute and reaches a peak in 40-60 minutes; The effect of 4-5 hours The most pronounced effect is inhalation after two doses, further increasing doses does not lead to an increase in bronchial chances, but increases the likelihood of side effects (tremor, headache, dizziness). While affects mukotiliarnyi Cl (with chronic bronchitis increase it to 36%), stimulates the secretion of mucus, activates the mertzatelnogo cancer. It stops the release of mediators of inflammation fat cells bazofilov and, in particular, анти-IgE-индуцированны�� gistamina release eliminates antigenzawisimoe suppression mukotiliarnogo transport and the factor hemotaksisa Klebsiella. Warn of allergen induced bronchoconstriction. Can lead desencitizatiou and reducing the number of бета-адренорецепторо�� incl. Lymphocytes at. And some metabolic effects, reduces the content of potassium in the plasma affects glikogenoliz and that insulin has giperglikemiceski (especially in patients with bronchial asthma) and lipoliticeski effect increases the risk of azidoza.

Indications

Prevention and mild bronchospasm in bronchial asthma, symptomatic treatment bronchoobstructive syndrome (chronic bronchitis, chronic obstructive pulmonary disease, etc.), asthma night (prolongirovanne tabletirovanne forms); Preventing premature births.

Contraindications

Hypersensitivity, ischemic heart disease, arterial hypertension, in rhythm, heart failure, diabetes, Ray, feohromotsytoma violation of the kidney, I trimester of pregnancy.

Side-Effects

Dizziness, headache, tachycardia (with the pregnancy in the mother and fetus), incredible, gipotenzia, myocardial ischaemia, heart failure, 50.9, black light (possible death), reddening of arousal distal tremor, nausea, vomiting, dry mouth, loss of appetite, difficulty urinating, sweating, increase of blood glucose and free fatty acids gipokaliemia, allergic reactions in the form of eritema, oedema of difficulty breathing, the development of physical and mental Drug Dependence.

Specific guidance

When using aerosol measured to be clear that the following instructions : shaking cans of aerosol before every use, a clear Timing breaths and drug proceeds, as a deep, intense, a long breath, the delay breathing after inhalation drug for 10. People who find it difficult to comply with the correct breathing manoeuvre recommended to be used for inhalation drug supportive (speisera) adding breathing volume and mitigate inaccuracies asynchronous breaths.

Patient interaction

Increases activity CNS stimulants, hormones cardiotroponosti thyroid gland. Theofillin and ephedrine potenziruut toxic effects. Hormones, the synthesis inhibitors NG Tricyclic antidepressants and MAO blockers increase the risk for cardiovascular complications for inhalation narcosis and levodopa-heavy jeludockovh arrhythmias. Reduces the beta-blokatorov (including ophthalmic form), antigipertenziveh funds antianginalny effect nitrates. It increases the likelihood glycoside intoxication.

Overdosing

Symptoms : tachycardia, ventricular fibrillation, the expansion of peripheral vessels, the reduction of AD increases heart emission gipoksemia, acidosis, gipokaliemia, giperglikemia, muscle tremor, headache, causing hallucinations and other psychotic Narushenia.lechenie : lifting drug and symptomatic therapy; Appointment бета-адреноблокаторо�� (selective), in patients with bronchial asthma requires extreme caution because of the risk of heavy bronhospasticescoy reaction.

Precautions

In order to enhance the effectiveness of therapy patient should teach proper use ingalatorom and early treatment of asthma under the supervision of medical personnel. Admission high doses salbutamola with acute asthma resulted in a subsequent attack near a turning previous (syndrome "ricocheta"). The plight amok suffocation break between ingalyatsiami must be at least 20 minutes. In the absence of minimal effect of inhalation or when expressed tremora, tachycardia, of the heart rhythm further uncontrolled use ingalatora counter and necessary treatment to the doctor. The risk of complications increases both in the long duration of treatment, and in an abrupt cancellation preparation.

Dosing and Administration

Inhalation in the form of aerosol measured, as well as dry powders inhalations. For edema beginning attack suffocation ingaliruut 1-2 doses. In the absence of the effect in five minutes can be re-inhalation. Follow inhalation producing intervals with 4-6 hrs (up to six times a day). For regular use for inhalation 1-2 2-4 times / day (in particular, in order to improve the penetration of basic anti drugs to distalnam divisions Bronchus tree for 15 to 20 minutes after inhalation to kromoglikata sodium nedokromila sodium or inhalation glukokortikoida); Prevention of bronchospasm, for 15 to 20 minutes before contact with the cold air. The plight amok possible introduction inhalation solution using different structures therapy for 5-15 minutes, the interval between ingalyatsiami - 4h Inside, as an adjunct to the ineffectiveness of inhalants, 1 tab. 3-4 times a day; prolongirovanne forms, and 1 table. overnight, or at one table. morning and evening. Where there are threats of cancer-into-1 table. (4 mg) every 2-3 hours, and then for two days on one table. every 4 h, in the coming days on one table. through 6900, in a few days, to a complete halt reductions uterus.

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